Simple blood test could spare thousands from unnecessary chemo

NCT ID NCT06076811

Recruiting now Knowledge-focused Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a blood test for tumor DNA can better predict if colorectal cancer will come back after surgery. Currently, doctors use tumor tissue to decide who needs chemotherapy, but many patients get chemo they may not need. The test checks for cancer DNA in the blood, which could be a more accurate way to find hidden cancer cells. Researchers will follow 1,600 patients to see if the test works in real-world practice.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: liquid biopsy (circulating tumor DNA test)
What this could lead to: If successful, this blood test could become a standard way to identify which colorectal cancer patients need chemotherapy after surgery, sparing others from unnecessary side effects.
What could go wrong: This is an observational study, not a treatment trial. The test may not prove more accurate than current methods, and results may not change practice immediately.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal carcinoma colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOCARCINOMA COLORECTAL CANCER COLORECTAL CANCER STAGE I COLORECTAL CANCER STAGE II COLORECTAL CANCER STAGE III COLORECTAL NEOPLASMS

Contacts and locations

Locations

Aalborg University Hospital
RECRUITING

Aalborg, North Denmark, 9000, Denmark
Aarhus University Hospital
RECRUITING

Aarhus, Central Jutland, 8000, Denmark
Bispebjerg Hospital
RECRUITING

Copenhagen, Capital Region of Denmark, 2400, Denmark
Gødstrup Hospital
RECRUITING

Herning, Central Jutland, 7400, Denmark
Herlev Hospital
NOT_YET_RECRUITING

Herlev, Capital Region of Denmark, 2730, Denmark
Odense University Hospital
RECRUITING

Odense, The Region of Southern Denmark, 5000, Denmark
Regional Hospital Horsens
RECRUITING

Horsens, Central Jutland, 8700, Denmark
Regional Hospital Randers
RECRUITING

Randers, Central Jutland, 8930, Denmark
Regional Hospital Viborg
RECRUITING

Viborg, Central Jutland, 8800, Denmark
Vejle Hospital
RECRUITING

Vejle, 7100, Denmark

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