New cancer cocktail enters human testing
NCT ID NCT06657144
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing an experimental drug called CHS-114 combined with the immunotherapy toripalimab, with or without standard chemotherapy, in 154 people with advanced or metastatic solid tumors. The main goal is to see if the combination is safe and to get an early look at whether it can shrink tumors. Researchers are also checking how long any response lasts.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CHS-114 (an experimental drug) combined with toripalimab (an immunotherapy) and possibly chemotherapy drugs (5-fluorouracil, cisplatin)
What this could lead to
If successful, this could point toward a new combination treatment option for people with advanced or metastatic solid tumors that have not responded to other therapies.
What could go wrong
This is an early Phase 1 trial with only 154 participants, focused mainly on safety. The combination may not shrink tumors or could cause significant side effects. Results may not apply to all cancer types.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Changhua Christian Hospital
RECRUITINGChang-hua, Taiwan
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Chi Mei Hospital
RECRUITINGTainan, 736, Taiwan
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China Medical University Hospital
RECRUITINGTaichung, Taiwan
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Christus St Vincent Regional Medical Center
RECRUITINGSanta Fe, New Mexico, 87505, United States
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City of Hope
RECRUITINGDuarte, California, 91010, United States
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Comprehensive Cancer Center of Nevada
RECRUITINGLas Vegas, Nevada, 89169, United States
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David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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E-Da Cancer Hospital
RECRUITINGKaohsiung City, 824, Taiwan
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Henry Ford Health System
RECRUITINGDetroit, Michigan, 48202, United States
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Huntsman Cancer Institute, University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 11766, United States
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Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITINGKaohsiung City, Taiwan
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mackay Memorial Hospital
RECRUITINGTaipei, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Cheng Kung University Hospital
RECRUITINGTainan, 704, Taiwan
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Taiwan University Hospital
RECRUITINGTaipei, 10002, Taiwan
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ochsner Health
RECRUITINGNew Orleans, Louisiana, 70121, United States
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Prisma Health Cancer Institute
RECRUITINGGreenville, South Carolina, 29605, United States
Contact Email: •••••@•••••
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
Contact Email: •••••@•••••
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START Mountain Region, LLC.
RECRUITINGWest Valley City, Utah, 84119, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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START New York
RECRUITINGLake Success, New York, 11042, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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START San Antonio, LLC.
RECRUITINGSan Antonio, Texas, 78229, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taichung Veterans General Hospital
RECRUITINGTaichung, 40705, Taiwan
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Taipei Veterans General Hospital
RECRUITINGTaipei, 112, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Oncology - Central South
RECRUITINGAustin, Texas, 78731, United States
Contact Email: •••••@•••••
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The University of Arizona Cancer Center
WITHDRAWNTucson, Arizona, 85724, United States
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University of Colorado - Aurora Cancer Center
RECRUITINGAurora, Colorado, 80045, United States
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University of Pittsburg Medical Center _UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
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Virginia Oncology Associates
WITHDRAWNNorfolk, Virginia, 23502, United States
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Winship Cancer Center - Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact