New cancer cocktail enters human testing

NCT ID NCT06657144

Recruiting now Disease control Sponsor: Coherus Oncology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This early-stage trial is testing an experimental drug called CHS-114 combined with the immunotherapy toripalimab, with or without standard chemotherapy, in 154 people with advanced or metastatic solid tumors. The main goal is to see if the combination is safe and to get an early look at whether it can shrink tumors. Researchers are also checking how long any response lasts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CHS-114 (an experimental drug) combined with toripalimab (an immunotherapy) and possibly chemotherapy drugs (5-fluorouracil, cisplatin)
What this could lead to: If successful, this could point toward a new combination treatment option for people with advanced or metastatic solid tumors that have not responded to other therapies.
What could go wrong: This is an early Phase 1 trial with only 154 participants, focused mainly on safety. The combination may not shrink tumors or could cause significant side effects. Results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus colorectal adenocarcinoma colorectal neoplasm esophageal adenocarcinoma esophageal squamous cell carcinoma gastric adenocarcinoma gastric neoplasm gastroesophageal junction adenocarcinoma metastatic malignant neoplasm neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR METASTATIC SOLID TUMOR

Contacts and locations

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Locations

Changhua Christian Hospital
RECRUITING

Chang-hua, Taiwan
Chi Mei Hospital
RECRUITING

Tainan, 736, Taiwan

Contact Email: •••••@•••••
China Medical University Hospital
RECRUITING

Taichung, Taiwan
Christus St Vincent Regional Medical Center
RECRUITING

Santa Fe, New Mexico, 87505, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Comprehensive Cancer Center of Nevada
RECRUITING

Las Vegas, Nevada, 89169, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
E-Da Cancer Hospital
RECRUITING

Kaohsiung City, 824, Taiwan
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 11766, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, Taiwan
Mackay Memorial Hospital
RECRUITING

Taipei, Taiwan
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Ochsner Health
RECRUITING

New Orleans, Louisiana, 70121, United States
Prisma Health Cancer Institute
RECRUITING

Greenville, South Carolina, 29605, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
START Mountain Region, LLC.
RECRUITING

West Valley City, Utah, 84119, United States
START New York
RECRUITING

Lake Success, New York, 11042, United States
START San Antonio, LLC.
RECRUITING

San Antonio, Texas, 78229, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 40705, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Texas Oncology - Central South
RECRUITING

Austin, Texas, 78731, United States
The University of Arizona Cancer Center
WITHDRAWN

Tucson, Arizona, 85724, United States
University of Colorado - Aurora Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Pittsburg Medical Center _UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
WITHDRAWN

Norfolk, Virginia, 23502, United States
Winship Cancer Center - Emory University
RECRUITING

Atlanta, Georgia, 30322, United States

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