New antibody drug takes aim at Hard-to-Treat cancers

NCT ID NCT03715933

Recruiting now Disease control Sponsor: Inhibrx Biosciences, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new drug called INBRX-109 in people with advanced solid tumors, including Ewing sarcoma and colorectal cancer. The drug is designed to attach to a protein on cancer cells and trigger their death. The main goals are to check safety and see if the drug can shrink tumors. About 411 participants will take part in this study.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma Ewing sarcoma sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOCARCINOMA EWING SARCOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Academisch Ziekenhuis Leiden
RECRUITING

Leiden, Netherlands
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Children's Hospital of Philadelphia- Center for Childhood Cancer Research
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
COMPLETED

Cleveland, Ohio, 44195, United States
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Emory University - Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20123, Italy
Great North Children's Hospital
RECRUITING

London, EC4V 3BJ, United Kingdom
Gustave Roussy
RECRUITING

Villejuif, 94805, France
HonorHealth Research Institute
COMPLETED

Scottsdale, Arizona, 85258, United States
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
La Fondazione e l'Istituto di Candiolo
RECRUITING

Candiolo, 10060, Italy
NEXT Oncology
COMPLETED

San Antonio, Texas, 78229, United States
NEXT Oncology - Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Precision NextGen Oncology and Research
RECRUITING

Beverly Hills, California, 90212, United States
Royal Manchester Children's Hospital
RECRUITING

Manchester, M13 9WL, United Kingdom
START Midwest Michigan, PC
RECRUITING

Grand Rapids, Michigan, 49546, United States
Sarcoma Oncology Center
RECRUITING

Santa Monica, California, 90403, United States
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Chicago
COMPLETED

Chicago, Illinois, 60637, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University College London Hospital
RECRUITING

London, NW1 2PG, United Kingdom
University Medical Center Groningen
RECRUITING

Groningen, Netherlands
University of California, San Diego (UCSD) - Moores Cancer Center
WITHDRAWN

San Diego, California, 92093, United States
University of California, San Francisco (UCSF)
RECRUITING

San Francisco, California, 94110, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19106, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Vanderbilt University School of Medicine
RECRUITING

Nashville, Tennessee, 37232, United States

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