New immune cell therapy targets Hard-to-Treat cancers

NCT ID NCT06218914

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 29, 2026 · Updated 5 times

Summary

This early-stage trial tests a new type of immunotherapy where a patient's own T cells are genetically engineered to recognize and attack cancer cells with a specific KRAS G12D mutation. The study includes adults with advanced lung, colorectal, pancreatic, or endometrial cancers that have not responded to standard treatments. The main goals are to check safety and find the right dose, while also looking for signs of tumor shrinkage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: engineered T cells (NT-112 and AZD0240) targeting KRAS G12D mutation
What this could lead to: If successful, this could lead to a new treatment option for people with advanced cancers that have a specific KRAS mutation, potentially shrinking tumors or slowing disease progression.
What could go wrong: This is a very early (Phase 1) trial with only 108 participants, so safety and effectiveness are not yet proven. The treatment may cause serious side effects, and it only works for people with a specific genetic profile (KRAS G12D and certain HLA types).

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal carcinoma colorectal neoplasm endometrial cancer endometrium neoplasm neoplasm non-small cell lung carcinoma pancreatic adenocarcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CARCINOMA ENDOMETRIAL CANCER KRAS G12D NON-SMALL CELL LUNG CANCER PANCREATIC DUCTAL ADENOCARCINOMA SOLID TUMOR, ADULT

Contacts and locations

Locations

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Duarte, California, 91010, United States
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Los Angeles, California, 90095, United States
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Newport Beach, California, 92663, United States
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Jacksonville, Florida, 32224, United States
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Chicago, Illinois, 60637, United States
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Westwood, Kansas, 66205, United States
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Boston, Massachusetts, 02115, United States
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St Louis, Missouri, 63110, United States
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New York, New York, 10016, United States
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New York, New York, 10065, United States
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Portland, Oregon, 97213, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15237, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75246, United States
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Galveston, Texas, 77555, United States
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Houston, Texas, 77030, United States
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Milwaukee, Wisconsin, 53226, United States

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