COLORECTAL ADENOCARCINOMA

This study is testing whether a combination of three drugs—temozolomide, cisplatin, and nivolumab—can help control advanced colorectal cancer that has stopped responding to standard chemotherapy. It is for patients whose tumors have a specific genetic profile (MMR-proficient). Th…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 48 adults whose cancer has spread and is a specific type called microsatelli…

This is the first study in people testing a new drug called TST003 for patients with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and see if the drug can help shrink tumors, especially in c…

This study is testing whether combining chemotherapy with surgery to remove lung tumors works better than either treatment alone for colorectal cancer that has spread only to the lungs. Patients are divided into low-risk and high-risk groups, with each group receiving different t…

This large study is testing whether adding a high daily dose of vitamin D to standard chemotherapy and a targeted drug (bevacizumab) can better control metastatic colorectal cancer. It involves 455 patients whose cancer has spread and who have not yet received treatment for it. T…

This study is testing if a standard chemotherapy drug (oxaliplatin) can make advanced colon cancer more visible to the immune system. Researchers then add an immunotherapy drug (nivolumab) to see if this combination can stop the cancer from growing for a longer time. The trial is…