New combo therapy aims to stop colorectal cancer from coming back
NCT ID NCT06434376
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding a personalized immune treatment to standard chemotherapy can prevent cancer recurrence in colorectal cancer patients who have minimal residual disease (MRD) after surgery. Ten adults aged 18-80 with stage II (high-risk) or stage III colorectal cancer will receive routine chemo plus a custom-made immune modulator based on their tumor's unique features. The goal is to see if this approach improves response rates and delays or prevents relapse.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- personalized immune modulators (neoantigen-based) plus routine chemotherapy
- What this could lead to
- If it works, this could point toward a way to reduce the risk of cancer returning after surgery for patients with signs of remaining disease.
- What could go wrong
- This is a very early (Phase 1) trial with only 10 participants, so results may not apply broadly. The personalized approach is complex and may not be effective or feasible for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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No 1111 Wenzhou Avenue (East Section), Longwan District, Wenzhou City, Zhejiang Province, China
Wenzhou, Zhejiang, 325024, China
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