Could chemo around surgery beat cancer spread in the belly?
NCT ID NCT02758951
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving chemotherapy before and after surgery (plus heated chemo directly into the abdomen) helps people with colorectal cancer that has spread to the lining of the abdomen live longer. About 358 adults with resectable disease are randomly assigned to either the chemo-plus-surgery group or surgery alone. The main goal is to see if the combined approach improves overall survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemotherapy (CAPOX, FOLFOX, FOLFIRI, or fluoropyrimidine monotherapy)
- What this could lead to
- If it works, this could show that adding chemotherapy around surgery helps people with colorectal cancer that has spread to the abdomen live longer.
- What could go wrong
- This is a mid-to-late stage trial, but results are not yet available. Chemotherapy can cause side effects, and the added treatment may not improve survival compared to surgery alone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Amsterdam University Medical Centre, Location VUMC
Amsterdam, Netherlands
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Catharina Hospital
Eindhoven, Netherlands
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Erasmus University Medical Centre
Rotterdam, Netherlands
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Netherlands Cancer Institute
Amsterdam, Netherlands
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Radboud University Medical Centre
Nijmegen, Netherlands
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St. Antonius Hospital
Nieuwegein, Netherlands
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University Medical Centre Groningen
Groningen, Netherlands
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University Medical Centre Utrecht
Utrecht, Netherlands
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Ziekenhuis Oost-Limburg
Genk, Flanders, 3600, Belgium
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