New combo aims to outsmart stubborn colorectal cancer
NCT ID NCT05504252
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether combining the immunotherapy nivolumab (Opdivo) with the chemotherapy oxaliplatin can help control or shrink metastatic colorectal cancer that is mismatch repair proficient (pMMR) or microsatellite stable (MSS)—types that usually don't respond well to immunotherapy alone. The study includes 80 adults with measurable tumors who haven't had prior chemotherapy for their advanced disease. Researchers hope the oxaliplatin will make the tumors more sensitive to nivolumab, potentially leading to longer-lasting disease control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nivolumab (Opdivo) and oxaliplatin (with 5-fluorouracil and folinic acid)
What this could lead to
If successful, this combination could offer a new way to control or shrink metastatic colorectal cancer that is hard to treat with standard therapies.
What could go wrong
This is a small, early-phase trial (80 people) with no results yet. The approach may not work for all patients, and side effects from the drugs could be serious.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Akershus University Hospital
Lørenskog, Akershus, 1478, Norway
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Oslo University Hospital
Oslo, Akershus, 0424, Norway
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St Olavs Hospital
Trondheim, Trøndelag, 7006, Norway