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New pill targets Hard-to-Treat cancers in early trial

NCT ID NCT06004245

Recruiting now Disease control Sponsor: Vividion Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This early-stage study is testing an experimental oral drug, VVD-133214, in people with advanced solid tumors that have specific genetic features (MSI or dMMR). The drug works by blocking a protein that helps these cancers grow. The study will check safety and how well the drug works alone or combined with other treatments. About 280 participants will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm Microsatellite Instability

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS COLORECTAL CANCER

Contacts and locations

Locations

  • Alfred Hospital

    RECRUITING

    Melbourne, Victoria, 3181, Australia

  • Asan Medical Center

    ACTIVE_NOT_RECRUITING

    Seoul, 05505, South Korea

  • BCCA-Vancouver Cancer Centre

    COMPLETED

    Vancouver, British Columbia, V5Z 4E6, Canada

  • CLCC Leon Berard Lyon

    COMPLETED

    Lyon, 69008, France

  • City of Hope Cancer Center

    RECRUITING

    Duarte, California, 91010, United States

  • City of Hope at Irvine Lennar

    RECRUITING

    Irvine, California, 91355, United States

  • Clinica Universidad de Navarra Madrid

    RECRUITING

    Madrid, Madrid, 28027, Spain

  • Clinica Universitaria de Navarra

    ACTIVE_NOT_RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Duke University

    COMPLETED

    Durham, North Carolina, 27705, United States

  • Emory University School of Medicine

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Gustave Roussy

    RECRUITING

    Villejuif, 94805, France

  • Hospital Clinico Universitario de Valencia

    ACTIVE_NOT_RECRUITING

    Valencia, Valencia, 46010, Spain

  • Kyungpook National University Chilgok Hospital

    NOT_YET_RECRUITING

    Daegu, 41404, South Korea

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • National Cancer Center

    NOT_YET_RECRUITING

    Gyeonggi-do, 10408, South Korea

  • Norton Cancer Institute - MDC

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • Oklahoma University Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73170, United States

  • Princess Margaret Cancer Center

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

  • Rigshospitalet

    RECRUITING

    København Ø, 2100, Denmark

  • Royal Marsden Hospital (Sutton)

    RECRUITING

    Sutton, SM2 5PT, United Kingdom

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • SCRI Oncology Partners

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • START Los Angeles

    NOT_YET_RECRUITING

    Los Angeles, California, 90025, United States

  • START Madrid. Centro Integral Oncologico Clara Campal

    RECRUITING

    Madrid, Madrid, 28050, Spain

  • START Midwest

    NOT_YET_RECRUITING

    Grand Rapids, Michigan, 49546, United States

  • START Mountain Region

    NOT_YET_RECRUITING

    West Valley City, Utah, 84119, United States

  • START San Antonio

    NOT_YET_RECRUITING

    San Antonio, Texas, 78229, United States

  • Samsung Medical Center

    NOT_YET_RECRUITING

    Seoul, 06355, South Korea

  • Sarah Cannon Research Institute

    RECRUITING

    London, W1G 6AD, United Kingdom

  • Sarawak Public Hospital

    RECRUITING

    Kuching, Sarawak, 93586, Malaysia

    Contact Email: •••••@•••••

  • Seoul National University Bundang Hospital

    ACTIVE_NOT_RECRUITING

    Seongnam-si, 13620, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Severance Hospital

    NOT_YET_RECRUITING

    Seoul, 33732, South Korea

  • St Vincents Sydney

    RECRUITING

    Darlinghurst, New South Wales, 2010, Australia

    Contact Email: •••••@•••••

  • The Christie

    ACTIVE_NOT_RECRUITING

    Manchester, M20 4BX, United Kingdom

  • UZ Leuven Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

  • University of Michigan

    NOT_YET_RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • Vall d'Hebron Institute of Oncology (VHIO), Barcelona

    RECRUITING

    Barcelona, BARCELONA, 08035, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.