RECTAL CANCER

This study is testing a two-part treatment given before surgery for stage II-III rectal cancer. First, patients receive a short, focused course of radiation designed to spare certain lymph nodes. Then, they receive an immunotherapy drug (a PD-1 inhibitor) to help the immune syste…

This study is testing if adding an immunotherapy drug (Serplulimab) to standard chemotherapy before surgery works better for people with a certain type of locally advanced rectal cancer. It will involve 128 patients who have not yet had treatment. Half will get the standard chemo…

This study is testing if a specially formulated turmeric extract (curcumin) can protect the bowels from severe inflammation and damage caused by radiation and chemotherapy in people with rectal cancer. The main goal is to see if taking the supplement during treatment lowers the r…

This study is testing whether a combination of chemotherapy and radiation can effectively treat early rectal cancer, allowing patients to avoid major surgery that often leads to permanent bowel problems. Patients can choose between standard surgery or this organ-preserving treatm…

This study is testing a new medical device that delivers radiation directly to rectal tumors. The goal is to see if this approach can effectively control cancer while allowing patients to avoid major surgery and a permanent colostomy bag. Researchers will enroll 20 patients to ch…

This large national study aims to see if adding immunotherapy drugs to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with high-risk rectal cancer. It will also compare two different lengths of radiation treatment. The goal is to shrink tu…

This study is testing if adding a dietary supplement called β-hydroxybutyrate (a type of ketone) to a standard combination of short radiation, chemotherapy, and immunotherapy can improve results for people with locally advanced rectal cancer. It will involve 48 adults who have no…

This study aims to find the safest and most effective way to remove urinary catheters after rectal cancer surgery. It will compare removing the catheter after 24 hours, after 48 hours, or using a personalized plan based on a patient's risk of bladder problems. The goal is to redu…

This study is testing whether giving chemotherapy after surgery can prevent rectal cancer from returning in patients who are at high risk. Researchers will use a special blood test to identify patients who have tiny amounts of cancer DNA left after their operation. About 103 pati…

This study is testing if a new injectable drug, called IP-001, can help prevent cancer from returning after a standard heat-based treatment (ablation) for colorectal cancer that has spread only to the liver. Researchers want to see if injecting IP-001 into the treated tumor area …

This study is testing a new combination treatment for people with high-risk, locally advanced rectal cancer. It aims to see if using a shorter, more intense course of radiation along with chemotherapy and an immunotherapy drug is safe and effective at shrinking or eliminating the…

This study aims to find the best way to treat people with rectal cancer that has also spread to the liver. It will follow 550 patients who first receive a strong chemotherapy regimen called FOLFIRINOX. The main goal is to see how many patients can later have successful surgery to…

This study aims to find the best way to manage small leftover spots in rectal cancer patients who have already had chemoradiation. It will compare two approaches: surgically removing these spots versus closely monitoring them without immediate removal. The goal is to see which me…

This study is testing a two-part treatment for a specific type of rectal cancer. First, patients receive a short, intense course of radiation. Then, they receive an immunotherapy drug called AK112. The main goal is to see if this combination can completely eliminate the tumor, po…

This study is testing whether a sensitive blood test can help doctors decide the best next step for patients with early-stage rectal cancer who have completed initial chemotherapy and radiation. The test looks for tiny bits of cancer DNA in the blood. Based on the test result, pa…

This study examines whether newer, less invasive endoscopic techniques can effectively treat certain rectal tumors compared to traditional surgery. Researchers will review medical records of 300 adults who had either endoscopic or surgical removal of rectal tumors between 2015 an…

This study aims to develop better MRI scan methods to predict which rectal cancer patients have completely responded to initial treatment and can safely avoid major surgery. Researchers will analyze MRI data from about 115 patients to create a tool that more accurately detects ti…

This study is testing a new artificial intelligence tool designed to detect leftover cancer cells after treatment and better predict if rectal cancer might return. The AI combines information from blood tests, scans, and medical records to look for early warning signs that curren…

This study is testing a simpler, shorter camera called a 'rectoscope' to check for regrowth after a rectal tumor has been removed. The goal is to see if this check can be done quickly in a clinic using just a suppository, instead of requiring strong oral bowel medicine and a long…

This study is testing whether taking capsules containing a patient's own probiotics can help reduce severe bowel problems that often occur after rectal cancer surgery and the closure of a temporary ileostomy. The trial will involve 40 patients who will take the probiotic capsules…

This study aims to see if a single biofeedback session helps people perform Kegel exercises better to improve bowel control after rectal cancer surgery. It will compare two groups: one doing Kegel exercises with biofeedback guidance, and one doing Kegel exercises alone. The goal …

This study aims to see if starting sildenafil (the drug in Viagra) early after surgery and radiation for rectal cancer can prevent long-term erectile dysfunction. It will involve 188 men who had normal sexual function before their cancer treatment. Participants will be randomly a…

This study aims to create a detailed map of how colon and rectal cancer spreads to nearby lymph nodes. Researchers will follow 1,200 patients who have had surgery for at least 5 years to see where cancer cells travel. The goal is to use this pattern information to help guide futu…