RECTAL CANCER

This study tests whether injecting a special solution (KRC-01) into rectal tumors before radiation can make the radiation work better. The solution increases oxygen inside the tumor, which helps radiation kill cancer cells. About 24 adults with advanced rectal cancer that hasn't …

This phase 2 trial is testing whether adding an experimental drug called DCSZ11 to standard radiation and chemotherapy can improve outcomes for people with a high-risk type of rectal cancer. The study will enroll 30 adults who have not had prior treatment. The goal is to see if t…

This study tests a combination of two types of radiation therapy for elderly or frail patients with rectal cancer who cannot or will not have surgery. The goal is to shrink or control the tumor while maintaining quality of life. Researchers will follow 80 participants for up to t…

This phase 2 trial tests whether a daily dexamethasone enema can prevent or reduce acute rectal injury in 40 rectal cancer patients undergoing pelvic radiotherapy. One group starts the enema early (day 10 of radiation), while the other starts only after injury occurs. The goal is…

This phase 2 trial tests a new approach for high-risk locally advanced rectal cancer. It combines a shorter course of radiation with chemotherapy (capecitabine and oxaliplatin) and an immunotherapy drug (serplulimab). The study will compare this combo to standard chemoradiation i…

This study tests whether a short course of radiation followed by three drugs (disitamab vedotin, sintilimab, and capecitabine) can completely eliminate tumors in people with advanced HER2-positive rectal cancer. About 29 adults aged 18-75 will receive the treatment before surgery…

This study tests whether a targeted chemoradiotherapy can completely eliminate early-stage rectal cancer, allowing patients to avoid surgery and keep their rectum. 90 adults with small, localized tumors will either receive standard surgery or the new treatment followed by close m…

This pilot study tests whether an Ayurvedic drug called Trishul can help shrink rectal tumors and improve survival. Forty adults with advanced rectal cancer will receive either Trishul or a placebo pill, in addition to their standard treatment (chemo-radiation and surgery). The s…

This study tests a device called ColoSeal ICD, placed during rectal cancer surgery to protect the bowel connection and reduce the need for a stoma (a bag on the belly for waste). About 250 adults aged 22-75 with rectal cancer will be split into two groups: one gets the device, th…

This phase II trial tests a new device called the Maastro applicator, which delivers high-dose radiation directly to rectal tumors. The goal is to see if it can safely eliminate the cancer and allow patients to avoid major surgery. Twenty adults with rectal cancer will receive th…

This phase 2 trial is testing a new approach for people with stage II-III rectal cancer. It combines short-course radiotherapy that spares the tumor-draining lymph nodes with a PD-1 inhibitor (a type of immunotherapy). The goal is to see if this combination can lead to a complete…

This study tests whether adding an immunotherapy drug (serplulimab) to standard chemotherapy before surgery can improve outcomes for people with a common type of locally advanced rectal cancer (MSS/pMMR). About 128 participants will be randomly assigned to receive either chemo al…

This study tests whether a new drug called IP-001, injected into the liver after standard heat-based tumor destruction, can help prevent colorectal cancer from coming back. About 717 adults with colorectal cancer that has spread only to the liver will be randomly assigned to rece…

This phase 2 trial tests a new approach for people with high-risk locally advanced rectal cancer. Participants will receive a short course of radiation with a boost to the tumor, combined with chemotherapy (capecitabine and oxaliplatin) and an immunotherapy drug (tislelizumab). T…

This study compares a new drain fixation method (extra-peritoneal tunneling) to the standard method after rectal cancer surgery. About 596 participants will be randomly assigned to one of the two groups. The goal is to see if the new method reduces drain movement and improves the…

This phase 2 trial tests a new approach for patients with a specific type of mid-low rectal cancer (pMMR/MSS). Participants receive a short course of radiation followed by six cycles of the immunotherapy drug ivonescimab. The goal is to see if this combination can make the cancer…

This study will compare two different PET/MRI scans to see which one is better at finding lymph node metastases in people with middle to high rectal cancer. Thirty participants will receive both types of scans before surgery. The goal is to see if the newer tracer, [68Ga]Ga-CTR-F…

This study will test whether a special type of MRI, called IVIM-MRI, can predict lymphovascular invasion (LVI) in rectal cancer patients before surgery. LVI is a sign that the cancer may spread, and knowing this ahead of time could help doctors choose the best treatment. The stud…

This study will test whether an artificial intelligence system can detect minimal residual disease—tiny amounts of cancer left after surgery—and predict recurrence in 700 people with rectal cancer. The AI combines blood tests, genetic data, and scans to create a more complete pic…

This study tests whether wearing tight compression garments on hands and feet during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by taxane or oxaliplatin drugs. About 358 breast and colorectal cancer patients will be randomly assigned to wear compression …

This study tests whether a daily Bergmann enema can prevent severe rectal injury caused by radiation therapy in 40 rectal cancer patients. Participants will receive the enema from the start of radiotherapy until 10 days after. The goal is to reduce the rate of moderate-to-severe …

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This study tests whether taking your own gut bacteria (autologous probiotics) can reduce bowel problems after ileostomy closure in rectal cancer patients. Forty adults who had rectal cancer surgery with a temporary ileostomy will receive capsules containing their own lactobacillu…

This study tests whether a personalized plan for removing urinary catheters after mid-low rectal cancer surgery can reduce the need for re-insertion. About 1,545 patients will be randomly assigned to one of three groups: catheter removal at 24 hours, at 48 hours, or an individual…

This study tests a highly absorbable form of curcumin (from turmeric) in 72 adults with mid-to-low rectal cancer who are getting chemoradiation before surgery. The goal is to see if curcumin can reduce severe gut side effects like diarrhea and rectal pain. Researchers will also c…

This study looks at whether a blood test that finds tiny bits of tumor DNA (ctDNA) can help doctors monitor rectal cancer more closely than standard scans. Researchers will collect blood and tissue samples from 60 adults with non-spreading rectal cancer before and after standard …

This study looks at where cancer spreads to lymph nodes in people with colon or rectal cancer. Researchers will examine tissue from 1200 patients who had surgery to remove their cancer. The goal is to find patterns that could help doctors better plan treatment in the future.

This study aims to develop a method using advanced MRI scans to predict whether rectal cancer has been completely eliminated after chemoradiation. About 115 patients will be enrolled to test the accuracy of this MRI-based prediction. If it works, some patients might safely avoid …

This study tests a new short camera called a rectoscope to check the lower bowel after rectal tumour removal. The goal is to see if it can be used in the clinic with a simple enema instead of strong bowel prep, making follow-up checks faster and reducing waiting lists. Thirty pat…

This study will compare treatment recommendations made by a large language model (AI) with those made by a team of cancer experts for 180 people with rectal cancer. The AI will analyze de-identified patient information and suggest a treatment plan. The goal is to see how often th…

This study will look at tumor samples and health records from 300 people who had surgery for rectal cancer. The goal is to find patterns in the tumor's immune environment that can predict which patients will respond well to chemotherapy or immunotherapy. This could help doctors i…

This study reviews medical records of 300 adults who had endoscopic or surgical removal of rectal tumors between 2015 and 2025. Researchers want to see if newer endoscopic methods are as safe and effective as traditional surgery. The goal is to help doctors choose the best approa…

This phase 2 trial tests whether a highly sensitive blood test (ctDNA) can help manage treatment for 200 people with early-stage rectal cancer. After standard chemotherapy and radiation, some patients will have their treatment guided by the blood test results instead of immediate…

This study looks at people with rectal cancer who have small leftover spots after chemoradiotherapy. One group will have these spots removed with a scope, while the other group will just be watched closely. The goal is to see which approach leads to better cancer control after on…