RECTAL CANCER

This study tests a combination of two radiation therapies for elderly or frail patients with rectal cancer who cannot undergo surgery. The goal is to see if this approach can completely control the tumor and improve quality of life. About 80 participants will receive external bea…

This study tests a new approach for people with a high-risk type of rectal cancer. It combines a shorter course of radiation with chemotherapy and an immunotherapy drug (serplulimab). The goal is to see if this combination works better than standard treatment at shrinking or elim…

This study tests whether giving chemotherapy after surgery can prevent rectal cancer from returning in people who still have cancer DNA in their blood. About 103 adults with high-risk rectal cancer and a positive blood test will either receive chemo or standard monitoring. The go…

This study looks at people with locally advanced rectal cancer who have small leftover spots in the rectum after chemoradiation. Doctors want to see if removing these spots with a scope (endoscopic resection) leads to better 1-year cancer control than simply watching them closely…

This study tests whether using a patient's own gut bacteria (autologous probiotics) can reduce severe bowel problems after temporary ileostomy reversal in rectal cancer survivors. About 40 adults who had rectal cancer surgery with a temporary ileostomy will receive their own cult…

This study tests a new drug (DCSZ11) combined with short radiation and chemotherapy for people with a high-risk type of rectal cancer that hasn't spread. The goal is to shrink or eliminate the tumor before surgery, potentially avoiding the need for a permanent colostomy. About 30…

This study tests whether adding an immunotherapy drug (Serplulimab) to standard chemotherapy before surgery can improve outcomes for people with a specific type of locally advanced rectal cancer (MSS/pMMR). About 128 participants will be randomly assigned to receive either the co…

This study tests if a new drug called IP-001, injected into the liver after standard heat ablation, can prevent colorectal cancer from coming back in people whose cancer has spread only to the liver. About 717 adults will be randomly assigned to receive ablation alone or ablation…

This study tests a new treatment approach for people with high-risk locally advanced rectal cancer. It combines a short course of radiation (with a boost to the tumor) along with chemotherapy and an immunotherapy drug before surgery. The goal is to see if this combination can com…

This study tests a new treatment plan for people with advanced rectal cancer that has a protein called HER2. Patients first get a short course of radiation, then a combination of three drugs: disitamab vedotin, sintilimab, and capecitabine. The goal is to see if this approach can…

This study looks at whether giving a strong chemotherapy combination called FOLFIRINOX before surgery can help more people with rectal cancer that has spread to the liver have successful removal of all cancer. About 550 adults with mid or low rectal cancer and liver metastases th…

This study tests a short course of radiation followed by a drug called ivonescimab in 30 people with a specific type of mid-low rectal cancer. The goal is to see if this combination can make the cancer disappear completely, possibly avoiding the need for surgery. Participants wil…

This study tests if adding immunotherapy to standard treatment (radiation and chemotherapy before surgery) helps more people with high-risk rectal cancer achieve complete remission. It also compares a shorter course of radiation to a longer one. About 435 adults with locally adva…

This study tests whether a short course of radiation that spares the lymph nodes, followed by an immunotherapy drug (PD-1 inhibitor), can completely eliminate rectal cancer before surgery. It includes 44 adults with stage II-III rectal cancer. The goal is to see if this approach …

This study is for people with early-stage rectal cancer. It tests whether using chemoradiotherapy (a combination of chemotherapy and radiation) can completely eliminate the tumor, allowing patients to safely avoid surgery and keep their rectum. Participants can choose between sta…

This study tests a new device called the Maastro applicator that delivers high-dose radiation directly to rectal tumors from inside the body. The goal is to see if it can safely and effectively destroy the cancer so that some patients may not need surgery. About 20 adults with re…

This study will compare two types of PET/MRI scans to see which one is better at finding cancer that has spread to lymph nodes in people with middle to high rectal cancer. About 30 patients who have not yet been treated will get both scans before surgery. The goal is to see if th…

This study looks at the best time to remove urinary catheters after surgery for mid-low rectal cancer. About 1,545 patients will be randomly assigned to have their catheter removed at 24 hours, 48 hours, or based on a personalized risk score. The goal is to see which approach red…

This study tests a highly absorbable form of curcumin (from turmeric) in 72 people with mid-to-low rectal cancer who are getting chemoradiotherapy before surgery. The goal is to see if curcumin can reduce severe gut side effects like diarrhea and rectal pain. Researchers will als…

This study tests a new short camera (rectoscope) to check for regrowth after rectal tumor removal. It aims to see if using this camera with a simple enema instead of strong bowel medicine can be done safely in the clinic, reducing waiting lists. The study will include 30 adults w…

This study looks at whether a simple blood test can detect genetic material from rectal cancer tumors (ctDNA) to predict if the cancer has fully responded to treatment. Researchers will follow 60 adults with non-spreading rectal cancer who receive standard chemotherapy and radiat…

This study tests whether a sensitive blood test (ctDNA) can help doctors decide the best treatment for people with early-stage rectal cancer. About 200 adults will be enrolled to see if using the blood test leads to better outcomes, like complete tumor disappearance or longer sur…

This study aims to develop a method using advanced MRI scans to predict whether rectal cancer has completely disappeared after chemoradiation. About 115 participants will be enrolled to test if MRI can accurately identify patients who could safely avoid surgery and instead be mon…

This study looks at where colorectal cancer spreads to lymph nodes in 1200 patients. Researchers want to find patterns that could help doctors better plan treatment. Participants will have their removed lymph nodes analyzed and be followed for at least 5 years after surgery.

This study looks at how newer, less invasive endoscopic techniques compare to standard surgery for treating early rectal tumors. Researchers will review medical records from 300 adults treated between 2015 and 2025 to see if these methods are safer and just as effective. The goal…

This study looks at tumor samples from 300 people who had surgery for rectal cancer. Researchers want to understand how the immune system reacts to different treatments, like chemotherapy and immunotherapy. The goal is to find ways to predict which patients might avoid surgery in…

This study aims to build an AI system that combines blood tests, tumor genetics, and scans to detect leftover cancer cells (minimal residual disease) earlier in people with rectal cancer. About 700 adults who plan to have surgery for rectal or esophageal cancer will join. The goa…