Triple therapy aims to wipe out rectal tumors before surgery
NCT ID NCT07297030
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a new approach for people with high-risk locally advanced rectal cancer. Participants will receive a short course of radiation with a boost to the tumor, combined with chemotherapy (capecitabine and oxaliplatin) and an immunotherapy drug (tislelizumab). The goal is to see if this combination can make the tumor disappear completely before any surgery, potentially improving long-term outcomes. The study plans to enroll 37 adults aged 18 to 75.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Short-course radiotherapy with simultaneous integrated boost, capecitabine, oxaliplatin, and tislelizumab (a PD-1 inhibitor)
- What this could lead to
- If successful, this could offer a more effective neoadjuvant treatment for high-risk rectal cancer, potentially increasing the chance of complete tumor disappearance before surgery.
- What could go wrong
- This is a small, early-phase trial with only 37 participants, so results may not apply to everyone. The combination of radiation, chemotherapy, and immunotherapy may cause severe side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RECTAL ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of colorectal surgery, the Sixth Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, 510000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can diet and vitamin c supercharge rectal cancer treatment?
- Digital nurse companion: could an app ease the burden of chronic illness?
- Which rectal cancer surgery preserves quality of life better? a study investigates
- AI as a surgical Co-Pilot: predicting difficulty in rectal cancer
- Can AI learn to grade endoscopy quality from video?
- Can precision protons spare rectal cancer patients from harsh side effects?