Dye-Free laser imaging could replace standard dye in colorectal surgery
NCT ID NCT07720505
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This study compares two imaging methods for checking blood flow to the bowel during colorectal surgery: the standard technique using a dye called indocyanine green (ICG) and a newer dye-free method called Laser Speckle Contrast Imaging (LSCI). About 30 adults having elective colon or rectal surgery with a bowel connection will have both imaging methods used during their operation. Surgeons will make decisions based only on the standard ICG images, while the LSCI images are collected for comparison. The goal is to see if LSCI can provide objective, dye-free perfusion assessment that matches or improves upon current practice.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Laser Speckle Contrast Imaging (LSCI) compared with indocyanine green (ICG) fluorescence imaging
- What this could lead to
- If LSCI proves as reliable as ICG, it could offer a safer, dye-free way to assess bowel perfusion during surgery, potentially reducing allergic reactions and simplifying the procedure.
- What could go wrong
- This is a small, early-stage observational study in 30 patients, so results may not generalize. LSCI might not match ICG's accuracy, and technical limitations could hinder its use in real-world surgery.
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Conditions
The condition(s) this trial relates to.
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The condition terms exactly as the trial's registrant entered them.
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