New combo aims to shrink rectal tumors before surgery

NCT ID NCT07509424

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a short course of radiation followed by three drugs (disitamab vedotin, sintilimab, and capecitabine) can completely eliminate tumors in people with advanced HER2-positive rectal cancer. About 29 adults aged 18-75 will receive the treatment before surgery. The goal is to see how many patients have no cancer left at the time of surgery or on follow-up scans.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••