Could a chemo cocktail replace radiation for rectal cancer?

This phase 3 trial is testing whether a powerful chemotherapy combination (mFOLFOXIRI plus bevacizumab) can be used instead of standard chemoradiation before surgery for people with high-risk locally advanced rectal cancer. The goal is to see if this approach can reduce the chance of cancer spreading and avoid the long-term side effects of radiation, such as pain and incontinence. About 582 participants will be randomly assigned to receive either the new chemo combo or standard treatment, and researchers will track how long they live without the cancer returning.