New combo therapy aims to shrink rectal tumors before surgery
NCT ID NCT06162650
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 study tests a total neoadjuvant therapy approach for stage II or III rectal cancer. Participants receive short-course radiotherapy followed by 9 cycles of mFOLFOX6 chemotherapy before any surgery. The goal is to see how many patients achieve a complete response, meaning no cancer remains detectable. The study is recruiting 42 adults in Taiwan.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Short-course radiotherapy and mFOLFOX6 chemotherapy
What this could lead to
If successful, this approach could increase the chance of complete tumor disappearance before surgery, potentially reducing the need for more aggressive treatments.
What could go wrong
This is a small, early-phase study with only 42 participants, so results may not apply to all patients. Side effects from radiation and chemotherapy can be significant.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Cheng Kung University Hospital
RECRUITINGTainan, 704, Taiwan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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