Radiation that skips lymph nodes may help rectal cancer patients keep their rectum
NCT ID NCT07068763
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests a new treatment for early-stage rectal cancer that has not spread to lymph nodes. Instead of radiating the whole pelvis, doctors give a short course of radiation only to the tumor, followed by chemotherapy and an immunotherapy drug. The goal is to shrink the cancer completely so patients can avoid major surgery and a permanent colostomy. The study enrolls 52 adults with a specific type of rectal cancer (MSS) and will measure how many achieve a complete response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
short-course radiation to the tumor only, capecitabine chemotherapy, and a PD-1/CTLA-4 bispecific antibody (Aiparolitoworixureli injection)
What this could lead to
If successful, this approach could allow more patients with early rectal cancer to avoid major surgery and a permanent colostomy by achieving a complete response with a combination of targeted radiation, chemotherapy, and immunotherapy.
What could go wrong
This is a small, early-phase (phase 2) trial with only 52 participants, so results may not apply to all patients. The combination therapy may cause significant side effects, and the long-term cancer control rates are still unknown.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sir run run shaw hospital
RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••