Radiation's immune secrets: new trial probes rectal cancer response

NCT ID NCT05943210

Recruiting now Knowledge-focused Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is looking at how short-course radiation therapy (5 days of treatment) affects the immune system in people with rectal cancer. Researchers will collect blood, stool, and tumor tissue samples before, during, and after radiation to study these changes. The goal is to better understand the body's response to radiation, which could help improve future treatments. About 25 adults with localized rectal cancer will take part across seven international centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Short course radiation therapy
What this could lead to: If successful, this study could reveal how radiation changes the immune environment in rectal cancer, potentially leading to better combination therapies.
What could go wrong: This is a small, early-stage observational trial (25 participants) focused on collecting data, not testing a new treatment. It may not directly improve patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm rectum adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Locations

New York Presbyterian Brooklyn Methodist Hospital
RECRUITING

Brooklyn, New York, 10065, United States
New York Presbyterian Hospital - Queens
NOT_YET_RECRUITING

New York, New York, 11355, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
The University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
Weill Cornell Medical College
RECRUITING

New York, New York, 10065, United States

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