Radiation's immune secrets: new trial probes rectal cancer response
NCT ID NCT05943210
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is looking at how short-course radiation therapy (5 days of treatment) affects the immune system in people with rectal cancer. Researchers will collect blood, stool, and tumor tissue samples before, during, and after radiation to study these changes. The goal is to better understand the body's response to radiation, which could help improve future treatments. About 25 adults with localized rectal cancer will take part across seven international centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Short course radiation therapy
What this could lead to
If successful, this study could reveal how radiation changes the immune environment in rectal cancer, potentially leading to better combination therapies.
What could go wrong
This is a small, early-stage observational trial (25 participants) focused on collecting data, not testing a new treatment. It may not directly improve patient outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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New York Presbyterian Brooklyn Methodist Hospital
RECRUITINGBrooklyn, New York, 10065, United States
Contact
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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New York Presbyterian Hospital - Queens
NOT_YET_RECRUITINGNew York, New York, 11355, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rutgers Cancer Institute of New Jersey
RECRUITINGNew Brunswick, New Jersey, 08901, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
Contact
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Weill Cornell Medical College
RECRUITINGNew York, New York, 10065, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••