New combo therapy targets hidden cancer cells in colorectal patients

NCT ID NCT07227636

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether two drugs, botensilimab and balstilimab, can clear remaining cancer DNA in people with colorectal cancer who still have signs of disease after standard treatments like surgery and chemotherapy. About 284 adults with a specific type of colorectal cancer (MSS) will receive the drug combination, then balstilimab alone. The goal is to see if this approach can eliminate hidden cancer cells and prevent the cancer from coming back.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER RECTAL CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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