Can less surgery for rectal cancer be just as safe?

NCT ID NCT06146946

Recruiting now Disease control Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial is investigating whether it is safe to skip the removal of a specific group of lymph nodes (the No.253 lymph nodes) during surgery for mid and low rectal cancer. The standard surgery removes these nodes, but this study compares the long-term survival of patients who have them removed versus those who do not. The goal is to see if a less extensive surgery can achieve the same cancer control, potentially leading to fewer side effects and a better recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Surgical procedure: laparoscopic rectal radical resection with or without dissection of the No.253 lymph node
What this could lead to: If successful, this could show that a less extensive surgery is just as safe, potentially reducing complications and improving recovery for rectal cancer patients.
What could go wrong: The trial is still in progress, and it's possible that omitting the lymph node dissection could lead to higher recurrence rates or lower survival, which would confirm the need for the more extensive surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Locations

Beijing Cancer Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100142, China
Cancer Hospital Chinese Academy of Medical Sciences
RECRUITING

Beijing, Chaoyang District, 100021, China
China-Japan Friendship Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100029, China
Chinese PLA General Hospital
NOT_YET_RECRUITING

Beijing, Beijng, 100141, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Peking Union Medical College Hospital
RECRUITING

Beijing, Beijing Municipality, 100021, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200025, China
West China Hospital Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610044, China

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