Cancer Institute And Hospital, Chinese Academy Of Medical Sciences

This study tests whether a special PET scan (68Ga-CTR-FAPI) can help surgeons remove all medullary thyroid cancer in one operation. About 150 newly diagnosed patients will be randomly assigned to have surgery guided by this scan or by standard methods. The goal is to see if the s…

This study tests whether a single injection of Telpegfilgrastim works better than multiple daily injections of Filgrastim to prevent fever and dangerously low white blood cell counts caused by chemotherapy in children and teens (ages 6-24) with solid tumors. About 132 participant…

This study tests whether combining a liver-directed procedure (TACE) with two immunotherapy drugs (atezolizumab and bevacizumab) before surgery can improve outcomes for people with liver cancer that has a high risk of coming back. About 30 adults with resectable liver cancer will…

This study tests two oral drugs, fuzuloparib and apatinib, given before surgery for people with advanced ovarian cancer that has a specific genetic marker (HRD-positive). The goal is to shrink tumors enough for complete removal and avoid chemotherapy. About 48 participants will r…

This study tests whether adding the immunotherapy drug sintilimab to standard chemotherapy after surgery can help prevent stage III stomach or gastroesophageal junction cancer from returning. About 70 adults who have had their tumor removed will receive the combination for up to …

This study tests whether adding the targeted drug anlotinib to whole-brain radiation helps control brain tumors better than radiation alone in people with small cell lung cancer. About 134 participants will receive either the combination or radiation only. The goal is to see if t…

This study tests whether giving a drug called anlotinib together with targeted radiation before surgery can safely treat soft tissue sarcoma in the arms, legs, or trunk. About 30 adults will receive this combination to see if it reduces major wound problems after surgery and impr…

This early-phase study tests a new treatment called Meta10-TIL for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells, which are modified in the lab to better fight cancer. The main goal is to check saf…

This study tests whether adding golidocitinib to standard PD-1 inhibitor maintenance therapy can help people with extensive-stage small cell lung cancer live longer without their cancer growing. About 20 adults who have not yet been treated for this advanced lung cancer will rece…

This study tests whether combining radiation therapy with an immunotherapy drug (sintilimab) works better than the standard TACE procedure to keep liver cancer from returning after surgery. It involves 286 adults with high-risk features like narrow surgical margins or microvascul…

This study tests a new treatment for men with advanced prostate cancer that has stopped responding to standard hormone therapy. The treatment uses specially designed immune cells (called CAR-NK cells) that are trained to find and attack prostate cancer cells. The main goals are t…

This early study tests a new treatment called GC511B for adults with small cell lung cancer that has come back or not responded to standard therapy. The treatment uses specially engineered immune cells (CAR T cells) to target a protein called DLL3 on cancer cells. The main goals …

This study tests a combination of drugs (liposomal mitoxantrone, capecitabine, and anlotinib) in children, adolescents, and young adults whose solid tumors have returned or not responded to treatment. The goal is to see if this combo can shrink tumors and control the disease. Par…

This study tests whether adding immune checkpoint inhibitors to standard chemotherapy before surgery can improve outcomes for people with locally advanced colorectal cancer. About 170 adults with stage II/III colorectal cancer will be randomly assigned to receive either the combi…

This study is testing whether a new, adaptive radiation boost can reduce side effects while still controlling prostate and bladder cancers. About 60 adults with these cancers will receive the treatment on a special MRI-guided machine. Researchers will track side effects and quali…

This early-phase study tests an inhaled mRNA dry powder vaccine called BMD006 for people with advanced lung cancer or solid tumors that have spread to the lungs. The vaccine is designed to train the immune system to attack tumor-associated antigens. The study aims to find a safe …

This study aims to find the best treatment plan for people with esophageal or esophagogastric junction cancer that cannot be removed by surgery. It will test adding immunotherapy (PD-1/PD-L1 antibodies) or targeted drugs to the standard chemoradiotherapy. About 2000 adults with s…

This study tests whether the drug tislelizumab, given after surgery, can help prevent high-risk stage I lung cancer from returning. About 108 adults whose tumors were removed but had certain high-risk features will receive the drug or a placebo. The main goal is to see if more pa…

This study tests a combination of an immunotherapy drug (adebrelimab) with three chemotherapy drugs given before and after surgery for people with locally advanced stomach or gastroesophageal junction cancer. The goal is to see if this approach can completely eliminate the tumor …

This study tests a combination of three drugs (nimotuzumab, toripalimab, and chemotherapy) as a first treatment for people whose nasopharyngeal cancer has come back or spread. The goal is to see if this mix can shrink tumors and improve survival. About 30 adults with a specific t…

This study tests whether a new drug, Trastuzumab rezetecan (SHR-A1811), works better than standard chemotherapy for people with HER2-Low breast cancer that has spread and is causing severe organ problems (visceral crisis). About 184 adults aged 18-75 will receive the drug every t…

This early-stage study tests a new drug called CREPT-618 in about 13 adults with advanced liver cancer that has not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. Researchers will also look at how the drug moves through the b…

This study is testing a new way of giving radiation before surgery for a rare type of cancer called retroperitoneal sarcoma. The goal is to see if this approach is safe and reduces complications during and after surgery. About 50 adults with this cancer will receive focused radia…

This study tests whether customizing local treatments (like radiation or surgery) based on how well the tumor responds to initial chemotherapy can help people with advanced breast cancer live longer without the disease getting worse. About 157 women with cancer in specific lymph …

This study tests a new drug combination for people with advanced stomach or gastroesophageal junction cancer that has not responded to initial treatment. About 60 participants will receive either a two-drug or three-drug combination to see if adding a third drug improves outcomes…

This early-phase study tests a new cell therapy called Anti-PSMA CAR NK cells in 10 men with metastatic castration-resistant prostate cancer (mCRPC) that has stopped responding to hormone therapy. The treatment uses modified immune cells to target a protein (PSMA) on cancer cells…

This study tests whether adding the drug ivonescimab to standard chemotherapy can shrink liver tumors from colorectal cancer that cannot be removed with surgery. About 40 adults will receive the combination every 3 weeks for up to 8 cycles. The goal is to see if the tumors become…

This study tests a new type of radiation therapy for prostate cancer that uses an MRI machine to guide the beam. It aims to deliver high doses of radiation more precisely, reducing damage to healthy tissue and side effects. The trial includes 50 men with either localized or limit…

This study tests whether adding an experimental immunotherapy (QL1706) to standard chemoradiation can help control locally advanced cervical cancer. About 30 women with stage III or IVA cervical cancer will receive the combination treatment. The goal is to see if it improves how …

This early-phase study tests an experimental therapy called V001 Injection, which creates cancer-fighting cells directly inside the body. It is for 50 adults with advanced blood or solid cancers that have not responded to standard treatments. The main goals are to check safety, f…

This study tests a new treatment called LK101, given together with standard immunotherapy drugs, for people with advanced lung cancer that has not responded to previous treatments. The goal is to see if the combination is safe and can shrink tumors. About 60 adults with non-small…

This study is for people who have had surgery for biliary tract cancer. It uses a special test called MiniPDX to see which chemotherapy drugs might work best for each person. The goal is to see if this personalized approach can help prevent the cancer from coming back. About 204 …

This study tests a combination of two drugs, low-dose cytarabine and thalidomide, in 50 adults with untreated Langerhans cell histiocytosis (LCH), a rare disease where immune cells build up and damage tissues. The goal is to see if this treatment can stop the disease from getting…

This early-stage study tests a single injection of umbilical cord blood cells (XJ-MK-002) in 16 adults aged 18-75 who have low platelets from cancer therapy. The main goal is to check safety and find the best dose. Researchers will monitor side effects and platelet counts for 28 …

This study looks at how well the drug tislelizumab works when given before surgery for people with a specific genetic type of stage II-III colorectal cancer (dMMR/MSI-H). About 30 participants will receive three cycles of the drug, then have surgery to remove the tumor. Researche…

This study tests a new treatment for advanced ovarian cancer patients who have a large amount of fluid in their belly (ascites) and have not responded to standard therapies. The treatment involves injecting specially activated immune cells (SK-NK cells) directly into the abdomen …

This study tests whether a combination of lenalidomide and dexamethasone can control Rosai-Dorfman disease, a rare disorder where immune cells build up and cause lumps. About 40 adults aged 18 to 80 who are newly diagnosed or have not responded to prior treatment will receive the…

This study aims to find the best treatment before surgery for esophageal cancer. It compares chemotherapy, chemoradiation, targeted therapy, and immunotherapy in 2000 adults with stage I-IVa disease. The goal is to improve survival and reduce side effects.

This study is testing a new, non-invasive urine test that looks for a protein called CREPT in cells shed from the bladder. The goal is to see if this test can catch bladder cancer early and track if it comes back, without needing a painful scope procedure. The study will include …

This study is testing a new type of PET/CT scan that uses a special tracer called Al18F-octreotide to find tumors that have SSTR proteins on their surface. The goal is to see how accurate this scan is at detecting these tumors. About 400 people with known or suspected SSTR-positi…

This study tests a drug called romiplostim N01 in children and young adults (ages 6-24) with cancer who have low platelets from chemotherapy. The goal is to see if weekly injections can safely raise platelet counts and reduce bleeding risk. About 50 participants will receive the …

This study collects long-term survival information from 109 patients with advanced squamous non-small cell lung cancer who previously received tislelizumab combined with chemotherapy in the RATIONALE-307 trial. The goal is to understand how well the treatment works over time and …

This study watches 500 lung cancer patients who received immunotherapy before any other treatment. Researchers want to see if removing the whole lung or just part of it leads to better outcomes, and whether surgery is better than other treatments like radiation. The goal is to le…

This study is looking at whether proteins in urine can help doctors predict how well pre-surgery treatment works for people with locally advanced colorectal cancer. Researchers will collect urine samples from 400 patients before and after treatment and use advanced technology to …