New gene therapy CREPT-618 enters human trials for liver cancer
NCT ID NCT07364357
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial is testing a new drug called CREPT-618 in 13 adults with advanced liver cancer who have not responded to standard treatments. The drug works by targeting a gene called CREPT, which may help control tumor growth. The main goals are to check safety, find the right dose, and see early signs of anti-cancer activity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CREPT-618 (a small nucleic acid drug targeting the CREPT gene)
- What this could lead to
- If this early trial shows safety and hints of tumor shrinkage, it could point toward a new treatment option for advanced liver cancer patients who have run out of standard therapies.
- What could go wrong
- This is a very early Phase 1 study with only 13 participants, focused mainly on safety and dosing. It is too small and early to know if CREPT-618 will actually work against liver cancer, and side effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEPATOCELLULAR CARCINOMA (HCC) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
RECRUITINGBeijing, 100021, China
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a triple therapy shrink untreatable liver tumors?
- Breath of life: new test could sniff out gut cancers before they spread
- Immune cell therapy takes on untreatable liver cancer
- Could your own immune cells keep liver cancer from coming back?
- New ultrasound technique could reveal hidden blood vessels in liver tumors
- New imaging tracer could spot hidden cancers and fibrosis in one scan