Rectal cancer patients may avoid surgery with new Chemo-Radiation combo
NCT ID NCT04864067
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a treatment plan for locally advanced rectal cancer that uses a short course of radiation followed by chemotherapy, aiming to avoid surgery. 39 patients were enrolled. The goal was to see if the cancer could be completely controlled without an operation, using a 'watch and wait' approach for those who responded well. The study measured how many patients had a complete response lasting more than a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Oxaliplatin, 5-Fluoracil, Leucovorin, Capecitabine (chemotherapy drugs) and radiation therapy
What this could lead to
If successful, this approach could allow some patients with locally advanced rectal cancer to avoid major surgery and its side effects, while still controlling the disease.
What could go wrong
This is a small, single-arm Phase 2 trial with only 39 participants, so results may not apply to everyone. The long-term safety and effectiveness compared to standard treatment are not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Complejo Asistencial Doctor Sótero del Rio
Santiago, RM, Chile
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Hospital La Florida
Santiago, RM, Chile
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Hospital Padre Hurtado
Santiago, RM, Chile