Rectal cancer patients may avoid surgery with new Chemo-Radiation combo

NCT ID NCT04864067

Completed Disease control Sponsor: Servicio de Salud Metropolitano Sur Oriente Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a treatment plan for locally advanced rectal cancer that uses a short course of radiation followed by chemotherapy, aiming to avoid surgery. 39 patients were enrolled. The goal was to see if the cancer could be completely controlled without an operation, using a 'watch and wait' approach for those who responded well. The study measured how many patients had a complete response lasting more than a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oxaliplatin, 5-Fluoracil, Leucovorin, Capecitabine (chemotherapy drugs) and radiation therapy
What this could lead to: If successful, this approach could allow some patients with locally advanced rectal cancer to avoid major surgery and its side effects, while still controlling the disease.
What could go wrong: This is a small, single-arm Phase 2 trial with only 39 participants, so results may not apply to everyone. The long-term safety and effectiveness compared to standard treatment are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Locations

Complejo Asistencial Doctor Sótero del Rio

Santiago, RM, Chile
Hospital La Florida

Santiago, RM, Chile
Hospital Padre Hurtado

Santiago, RM, Chile

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