Real-Time margin check during rectal cancer surgery may cut recurrence

NCT ID NCT07398716

Completed Knowledge-focused Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether checking the removed tissue during surgery (frozen section) helps ensure all cancer is removed in people with mid or low rectal cancer who had radiation therapy. 99 patients were split into two groups: one had the extra check, the other had standard surgery. The goal was to see if the check reduces the chance of cancer coming back or needing more extensive surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intraoperative frozen section assessment
What this could lead to: If successful, this could show that checking margins during surgery helps reduce local cancer recurrence and the need for more extensive surgery.
What could go wrong: This is a small, completed study (99 patients) without a phase designation, so results may not be definitive or widely applicable. The procedure adds time to surgery and may not improve long-term outcomes.

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Conditions

The condition(s) this trial relates to.

rectal cancer rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECTAL CANCER

Contacts and locations

Locations

Bakırköy Dr. Sadi Konuk Training and Research Hospital

Bakırköy, Istanbul, 34147, Turkey (Türkiye)

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