Precision radiation targets hidden prostate cancer spots

NCT ID NCT06392295

Recruiting now Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving radiation to the para-aortic lymph nodes (located in the abdomen) can better control prostate cancer that has returned in a limited number of spots. Men with hormone-sensitive prostate cancer and up to five lesions seen on a PSMA PET/CT scan will receive daily radiation for five weeks, along with standard hormone therapy. The goal is to improve cancer control and maintain quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (photon or proton) to para-aortic and pelvic lymph nodes
What this could lead to: If successful, this approach could offer a more targeted way to control prostate cancer that has spread to lymph nodes, potentially delaying the need for stronger treatments.
What could go wrong: This is a small, early-phase trial (34 participants) and may not prove effective for everyone. Radiation to the abdomen carries risks such as fatigue, bowel or bladder irritation, and possible long-term side effects.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HORMONE SENSITIVE PROSTATE CANCER PROSTATE ADENOCARCINOMA PROSTATE CANCER

Contacts and locations

Locations

University of Miami
RECRUITING

Miami, Florida, 33136, United States

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