New pill cocktail aims to beat Hard-to-Treat myeloma

NCT ID NCT05530421

Recruiting now Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether a combination of three drugs (selinexor, venetoclax, and dexamethasone) can shrink tumors in people with a specific genetic subtype of multiple myeloma called t(11;14) that has come back or stopped responding to treatment. About 33 participants will take these pills daily. The main goal is to see how many patients achieve a partial or complete response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Selinexor, venetoclax, and dexamethasone (three drugs taken as pills)
What this could lead to: If this works, it could offer a new treatment option for people with a specific type of multiple myeloma that has stopped responding to other therapies.
What could go wrong: This is a small, early-phase study with only 33 participants. The combination may cause significant side effects, and it is not yet known if it will work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED AND REFRACTORY MULTIPLE MYELOMA

Contacts and locations

Locations

University of Miami, Lennar Foundation Medical Center
RECRUITING

Coral Gables, Florida, 33146, United States
University of Miami, Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Miami, Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITING

Deerfield Beach, Florida, 33442, United States

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