Engineered immune cells take on Hard-to-Treat myeloma in major trial

NCT ID NCT03651128

Completed Disease control Sponsor: Celgene Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a personalized cell therapy called bb2121 works better than standard drug combinations for people with relapsed and refractory multiple myeloma. About 386 participants were randomly assigned to receive either bb2121 or one of several standard regimens. The main goal is to see how long the cancer stays under control, with secondary goals including overall survival and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

bb2121 (a cell therapy made from the patient's own immune cells, engineered to attack myeloma cells)

What this could lead to

If successful, bb2121 could offer a more effective treatment option for people with multiple myeloma that has returned or stopped responding to standard therapies.

What could go wrong

This is an advanced phase 3 trial, but cell therapies can have serious side effects like cytokine release syndrome. The results may not apply to all patients, and long-term benefits are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

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Locations

Froedtert Hospital BMT Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Local Institution - 100

Indianapolis, Indiana, 46202-528, United States
Local Institution - 101

Pittsburgh, Pennsylvania, 15232, United States
Local Institution - 102

Tampa, Florida, 33612, United States
Local Institution - 103

Dallas, Texas, 75390, United States
Local Institution - 104

Baltimore, Maryland, 21201-1595, United States
Local Institution - 105

Seattle, Washington, 98104, United States
Local Institution - 106

Nashville, Tennessee, 37203, United States
Local Institution - 107

Madison, Wisconsin, 53792, United States
Local Institution - 108

Jacksonville, Florida, 32224, United States
Local Institution - 109

Birmingham, Alabama, 10016, United States
Local Institution - 110

Philadelphia, Pennsylvania, 19111, United States
Local Institution - 111

Philadelphia, Pennsylvania, 19107, United States
Local Institution - 112

Westwood, Kansas, 66205-2003, United States
Local Institution - 113

Durham, North Carolina, 27705, United States
Local Institution - 114

St Louis, Missouri, 63110, United States
Local Institution - 115

New York, New York, 10065, United States
Local Institution - 118

Dallas, Texas, 75246, United States
Local Institution - 119

New York, New York, 10029, United States
Local Institution - 120

Ann Arbor, Michigan, 48109-5936, United States
Local Institution - 122

Los Angeles, California, 90095, United States
Local Institution - 123

Boston, Massachusetts, 02215, United States
Local Institution - 124

Palo Alto, California, 94304, United States
Local Institution - 125

Rochester, Minnesota, 55905-0001, United States
Local Institution - 131

Atlanta, Georgia, 30322, United States
Local Institution - 132

Houston, Texas, 77030, United States
Local Institution - 134

Boston, Massachusetts, 02114, United States
Local Institution - 135

New York, New York, 10065, United States
Local Institution - 136

Salt Lake City, Utah, 84112, United States
Local Institution - 138

Hackensack, New Jersey, 07601, United States
Local Institution - 139

Chicago, Illinois, 60611, United States
Local Institution - 140

Atlanta, Georgia, 30342, United States
Local Institution - 141

Scottsdale, Arizona, 85259, United States
Local Institution - 142

Aurora, Colorado, 80045, United States
Local Institution - 145

Los Angeles, California, 90048, United States
Local Institution - 202

Leuven, 3000, Belgium
Local Institution - 251

Bern, 3010, Switzerland
Local Institution - 302

Calgary, Alberta, T2N 4N2, Canada
Local Institution - 303

Toronto, Ontario, M5G 2M9, Canada
Local Institution - 400

Paris, 75010, France
Local Institution - 401

Toulouse, 31059, France
Local Institution - 402

Lille, 59037, France
Local Institution - 403

Nantes, 44093, France
Local Institution - 511

Würzburg, 97080, Germany
Local Institution - 512

Heidelberg, 69120, Germany
Local Institution - 513

Düsseldorf, 40225, Germany
Local Institution - 514

Hamburg, 20246, Germany
Local Institution - 515

Cologne, 50937, Germany
Local Institution - 611

Bologna, 40138, Italy
Local Institution - 650

Amsterdam, 1081 HV, Netherlands
Local Institution - 651

Rotterdam, 3015 CN, Netherlands
Local Institution - 700

Oslo, N-0027, Norway
Local Institution - 750

Pamplona, 31008, Spain
Local Institution - 751

Salamanca, 37007, Spain
Local Institution - 800

Stockholm, SE-141 86, Sweden
Local Institution - 804

Isehara City, Kanagawa, 259-1193, Japan
Local Institution - 805

Shibuya-ku, 150-8935, Japan
Local Institution - 806

Bunkyō City, 113-8677, Japan
Local Institution - 807

Nagoya, 467-8602, Japan
Local Institution - 850

Leeds, LS9 7TF, United Kingdom
Local Institution - 851

London, SE5 9RS, United Kingdom
University Of Nebraska

Omaha, Nebraska, 68198-7680, United States