Blood test may speed up chemo decisions for deadly pancreatic cancer

NCT ID NCT07096362

Recruiting now Knowledge-focused Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can tell doctors within weeks if chemotherapy is shrinking a patient's pancreatic cancer. Currently, doctors wait about 8 weeks for a scan to see if treatment is working. The trial will enroll 50 people with metastatic pancreatic cancer who are starting their first chemotherapy. If the blood test shows the cancer is not responding, doctors may switch treatments earlier than usual.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 5-Fluorouracil, Oxaliplatin, Leucovorin (chemotherapy drugs)
What this could lead to: If successful, this could show that a simple blood test can help doctors decide sooner whether to switch chemotherapy for pancreatic cancer, potentially improving outcomes.
What could go wrong: This is a small, early-phase study (50 people) testing a new use of an existing test. The blood test may not reliably predict treatment response, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

pancreatic adenosquamous carcinoma pancreatic carcinoma with mixed differentiation pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Locations

University of Miami
RECRUITING

Miami, Florida, 33136, United States

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