University Of Miami

This study tests a single, high-dose radiation session aimed only at the tumor inside the prostate, not the whole gland, for early-stage prostate cancer. Some participants also receive a very short course of hormone therapy to boost effectiveness. For higher-risk patients, the si…

This study tests whether a therapy called functional electrical stimulation (FES) can improve arm and hand movement in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove system to stimulate muscles while participants practice tasks. The goal i…

This study is testing a new treatment plan for people with locally advanced rectal cancer. Instead of the usual approach, patients get chemotherapy first, followed by a higher dose of MRI-guided radiation. The goal is to see if this combination can eliminate the cancer completely…

This study tests a new therapy that uses a brain-computer interface to control spinal stimulation, helping people with incomplete spinal cord injury walk better. About 12 adults aged 18-70 with a traumatic injury at least 6 months old will participate. The therapy combines brain …

This study tests whether combining the drug regorafenib with a type of internal radiation (Y-90) can control advanced liver cancer that cannot be removed by surgery. About 30 adults with unresectable hepatocellular carcinoma will receive the combination. The goal is to see how ma…

This study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and works for children and young adults under 22 whose brain tumors have come back or not responded to treatment. About 20 participants will rec…

This study tests whether combining a weight-loss medication (tirzepatide) with a special diet can help people with mild Crohn's disease who are already on biologic therapy. The goal is to see if this approach is practical and helps control symptoms. The study will enroll 24 adult…

This study is testing a mobile health system that sends text reminders and offers support to help women with HIV stick to their treatment plan. The goal is to reduce stigma and medical mistrust while improving clinic attendance and medication use. About 80 women who have had trou…

This study looks at whether a drug called collagenase (CCH) is safe and works for men with Peyronie's disease who already tried platelet-rich plasma (PRP) injections. About 22 men with a penile curve between 30 and 90 degrees will get CCH injections into the plaque. The main goal…

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin depression care and whether their mood and viral levels improve within a year. Ten clinics in Cape Town will be randomly …

This study tests whether adding the drug axatilimab to a standard light-based blood treatment (ECP) can better control chronic graft-versus-host disease (cGVHD), a long-term complication after a stem cell transplant. About 49 people aged 12 and older who have already tried at lea…

This study tests whether a combination of three drugs (selinexor, venetoclax, and dexamethasone) can better control a certain type of multiple myeloma that has come back or not responded to treatment. About 33 adults with a specific genetic marker (t(11;14)) will receive the drug…

This study looks at how well women of African ancestry with ovarian cancer tolerate a maintenance drug called niraparib after initial treatment. Niraparib blocks cancer cells from repairing their DNA, which may slow or stop tumor growth. Researchers will track side effects and ex…

This study looks at whether monitoring the immune response to cytomegalovirus (CMV) can help prevent CMV disease in lung transplant recipients. About 100 adults who are CMV-positive and awaiting a lung transplant will have their CMV immunity tracked after surgery. The goal is to …

This study looks at whether eating a Mediterranean-style diet before prostate cancer surgery can lower insulin levels and improve other health measures. Twenty men scheduled for prostate removal will follow a controlled diet for a short time. The goal is to see if diet changes ca…

This study tests a drug called loncastuximab tesirine in 50 adults with marginal zone lymphoma that has returned or not responded to prior therapy. The drug is designed to deliver a toxin directly to cancer cells. Researchers will measure how many participants achieve complete re…

This study tests whether combining a targeted immunotherapy (tebentafusp) with a liver-directed radiation procedure (Y-90 radioembolization) can help control metastatic uveal melanoma that has spread to the liver. About 30 adults whose cancer is mainly in the liver will receive b…

This study tests whether combining two drugs, epcoritamab and loncastuximab tesirine, can safely shrink or eliminate lymphoma in people whose cancer has returned or stopped responding to treatment. About 26 adults with relapsed or refractory large B-cell lymphoma will receive the…

This study is testing whether gently cooling the body (to about 91°F) within 24 hours of a severe neck spinal cord injury can help protect nerves and improve recovery. Researchers will compare nerve function and daily living skills in 120 adults who receive this cooling treatment…

This study tests whether community health workers can help people with moderate-to-severe sleep apnea stick to using their breathing machines at night. About 48 adults who have never used a PAP machine before will receive either motivational coaching from a health worker or stand…

This study tests a smoking cessation program in the construction industry, where safety managers are trained to help workers quit smoking. About 608 construction workers and their managers will participate. The goal is to find the most effective and cost-efficient way to reduce s…

This study tests whether briefly soaking a corneal graft in a plasma rich in growth factors (PRGF) before transplant surgery can reduce the loss of important eye cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal edema who need a corneal tran…

This study tests whether a diet made of familiar American foods like grilled meats, baked potatoes, and oatmeal can reduce inflammation and help control ulcerative colitis. About 122 adults aged 16-75 with mild to moderate symptoms will follow this diet for a set time. Researcher…

This study tests a shorter course of a drug combination called BrECADD for people with advanced Hodgkin lymphoma (stage 2B to IV). About 48 adults aged 18 to 60 will receive this treatment to see if it works well and is tolerable. Researchers will also check if a blood test for t…

This study tests whether DNA changes in the KIT gene can help doctors choose the right drug for people with advanced gastrointestinal stromal tumor (GIST). About 48 adults whose cancer has worsened on imatinib will receive sunitinib or regorafenib based on their tumor's DNA. The …

This study tests a counseling program designed to help Black women living with HIV take their medication regularly and achieve viral suppression. Participants must be Black, cis-gender women aged 18 or older, with a history of trauma and recent unsuppressed viral load. The progra…

This study tests a combination of three drugs—elranatamab, lenalidomide, and dexamethasone—in people newly diagnosed with multiple myeloma, a blood cancer. The goal is to see if this treatment can eliminate all signs of cancer in the bone marrow. About 104 participants will recei…

This study tests if a medicine called probenecid can improve sperm movement in men with spinal cord injury. Many of these men have enough sperm, but the sperm don't swim well, causing infertility. The trial will give the drug by mouth and measure changes in sperm count and qualit…

This study tests a parenting program designed to help Hispanic sexual minority youth (ages 13-19) and their families. The goal is to prevent or reduce drug use and depressive symptoms by improving parent support, acceptance, and family functioning. About 306 teens and their paren…

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study tests a web and mobile program called Healthy Together ("Juntos") designed for Hispanic teens and their parents. The goal is to prevent unhealthy weight gain and improve physical activity and diet. About 750 families will take part, with teens aged 12-15 who are not cu…

This study compares two ways of offering HIV prevention medication, hepatitis C treatment, and substance use disorder care through telehealth to 350 people who inject drugs. Participants must be HIV-negative and willing to stay in the area for 12 months. The goal is to see which …

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This study tests two strategies—direct distribution and referral—to see which better gets HIV self-test kits and PrEP information to people in the social networks of current PrEP users. About 320 participants will take part. The goal is to increase HIV testing and connect more pe…

This study tests a new way to help Latinx men at risk for HIV start and stay on PrEP, a daily pill that prevents HIV. It combines a one-stop-shop clinic, a social network support program, and a national pharmacy chain to make getting PrEP easier. Researchers will enroll 624 cis-g…

This study tests whether adding duloxetine, a nerve pain medication, to standard pain management can reduce the amount of narcotics needed after total hip replacement. About 64 adults undergoing hip replacement will receive either duloxetine or a placebo before and after surgery.…

This study explores whether combining magnetic brain stimulation, electrical spinal cord stimulation, and electrical muscle stimulation can improve hand, leg, and trunk function in people with spinal cord injury. About 25 participants, including both injured and healthy individua…

This study tests whether adding radiofrequency microneedling to a standard KTP laser treatment works better for rosacea than laser alone. Twenty adults with rosacea will have each side of their face treated differently to compare results. The goal is to reduce redness, bumps, and…

This study looks at whether low-load or high-load resistance training works better for improving muscle strength and everyday tasks in people with Parkinson's disease. Researchers will enroll 60 older adults with mild to moderate Parkinson's. Participants will do either light or …

This study is testing a therapy program called Unified Protocol for children and teens (ages 7-17) with anxiety or depression, along with their parents. The program uses cognitive-behavioral techniques to help manage emotions. Researchers will measure changes in symptoms and pare…

This study tests a non-drug therapy called CBIT (Comprehensive Behavioral Intervention for Tics) in 200 youth with tic disorders like Tourette's. The goal is to see if CBIT reduces tic severity and improves quality of life, while also understanding what makes the therapy work bes…

This study looks at whether a diet that includes longer overnight fasting and follows a Mediterranean eating pattern is possible for people with multiple myeloma or its early forms (MGUS or smoldering myeloma). Researchers want to see if participants can stick with the diet and i…

This study tests whether deep brain stimulation (DBS) can improve walking in people with spinal cord injury who still have some movement but cannot walk well on their own. Six adults aged 22 to 70 who have been injured for at least one year will receive DBS to a brain area called…

This study looks at sleep habits in people with gastrointestinal cancer and their sleep partners (like a spouse). It tests two different programs to help improve sleep quality and reduce insomnia. About 152 patient-partner pairs will join, and the study tracks sleep changes over …

This study tests whether watching a virtual reality experience before or during radiotherapy can lower anxiety and improve satisfaction for cancer patients. About 150 adults receiving radiation at the University of Miami will be randomly assigned to different VR techniques or a s…

This study looks at whether using a nasal high-flow device during a 6-minute walk test helps people with COPD walk farther and feel less breathless. About 30 adults with COPD who use little or no extra oxygen will take part. Researchers will compare how far they walk and how hard…

This study tests a short, 30-minute online program designed to help caregivers (parents or guardians) of children aged 4-10 with anxiety. The program is adapted for Latin, Haitian, and Haitian-American families. Researchers will measure changes in caregiver anxiety and how they s…

This study tests whether combining body illusions (tricks that change how you perceive your body) with mild brain stimulation can reduce nerve pain and improve sensation in people with spinal cord injury. Researchers will enroll 30 adults with long-lasting neuropathic pain. The g…

This study tests whether listening to binaural beats (special sound patterns) or your favorite music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. Fifty adults having outpatient joint replacement will be randomly assigned to one of the two sound…

This study looks at whether adding a community health worker (called a natural helper) to standard parent-child therapy helps families stick with the program and see better results. About 300 families with children aged 2 to 12 who have behavior problems or a history of abuse wil…

This study tests whether using ice packs, medicated witch-hazel pads, and a numbing spray can reduce pain after vaginal surgery. About 70 women will be randomly assigned to receive either this routine or standard care. The goal is to see if this simple approach improves recovery …

This study looks at whether offering nutrition counseling and exercise programs before and during radiation or chemoradiation helps head and neck cancer patients. Researchers want to see if patients find these services useful and easy to stick with. About 60 adults with non-sprea…

This study tests whether a magnesium supplement called Magnesium-L-Threonate can improve sleep quality and reduce pain in 64 adults after total knee or hip replacement surgery. Participants will take the supplement or a placebo and report changes in sleepiness and sleep quality. …

This study tests a Chinese herbal cream (with 1% menthol) to temporarily relieve pain and itching caused by radiation therapy. About 40 women with breast cancer who have had a mastectomy and will receive chest radiation will use the cream. The goal is to see if it reduces severe …

This study tests whether a special breathing tube (McMurray Enhanced Airway) can prevent low oxygen levels in patients sedated for a heart ultrasound. About 50 adults will be randomly assigned to receive either the new device or standard oxygen through a nose tube. The goal is to…

This study looks at whether a structured exercise program can help children, teens, and young adults (ages 12-39) with sarcoma complete more of their planned chemotherapy. Participants will either exercise or receive standard care. The goal is to see if exercise is feasible and h…

This study looks at whether a Mediterranean diet and exercise program can help lymphoma patients finish their chemotherapy with fewer side effects. About 140 adults with untreated Hodgkin or Non-Hodgkin lymphoma will take part. The goal is to see if this lifestyle approach improv…

This small study tests whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injury. Sixteen participants will receive the stimulation and be monitored for side effects, as well as changes…

This study tests a new digital game designed to help parents and children play together in a fun, guided way. The game includes activities meant to improve their relationship and boost parents' confidence in their parenting skills. Researchers will enroll 30 parent-child pairs to…

This study tests if Botox can reduce light sensitivity (photophobia) in people who have had a traumatic brain injury (TBI) at least a year ago. About 50 adults with chronic light sensitivity will receive Botox injections, and researchers will measure changes in pain and vision ov…

This study looks at whether a bikini-style incision or a traditional straight incision heals better after hip replacement in obese patients. About 110 people with a BMI of 30 or higher will take part. The goal is to see which cut leads to faster healing and higher satisfaction wi…

This study tests whether non-steroidal anti-inflammatory drugs (NSAIDs) can effectively control pain after robotic kidney cancer surgery, reducing the need for stronger opioid painkillers. About 110 adults undergoing this surgery will be randomly assigned to receive either NSAIDs…

This study compares three types of support for parents who lost a child to cancer at least six months ago and still have high grief levels. The programs are Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care. Researchers will measure changes in grief a…

This study looks at whether a workout program can help recreational video game players react faster and click more accurately. Researchers will measure changes in reaction time and mouse accuracy in 15 college students who play games at least one hour per week. The goal is to see…

This study looks at whether obstructive sleep apnea (OSA) is linked to problems with how the body processes fat. Researchers will compare fat metabolism in 100 adults with and without sleep apnea using a glucose test. The goal is to understand how fat tissue releases substances t…

This study tests a new approach to help syringe service programs offer routine HIV and Hepatitis C testing to people who inject drugs. Researchers will work with 40 programs to see if funding and support can increase testing and connect more people to care. The goal is to make te…

This study looks at how eating affects metabolism and heart health in men with and without spinal cord injury (SCI). Researchers will measure how much energy the body uses after a meal and how hungry participants feel. The goal is to understand these differences to improve future…

This study tests whether adding touch sensations (haptic feedback) to virtual reality can improve how children learn to read and spell. About 60 participants aged 6 and older will use special gloves that vibrate while they complete literacy tasks in VR. The goal is to see if this…

This study looks at two different ways to do power training (exercises that build speed and strength) in healthy adults aged 50 to 90. The goal is to see which method works best for improving muscle power and walking speed. About 45 participants will be followed over time, but no…

This study looks at how eating affects communication between the brain and stomach in people with and without spinal cord injury. Researchers will measure brain and stomach activity in 28 adults to understand gut-brain connections. The goal is to learn more, not to test a treatme…

This study collects blood samples from up to 700 people receiving stem-cell transplants for blood cancers and their donors. Researchers will analyze the samples to learn how the immune system rebuilds after transplant and what affects graft-versus-host disease. Participants provi…

This study is a large research program that invites people with ALS, their family members, and healthy volunteers to take part in various studies. The goal is to help scientists learn more about ALS and related diseases. No treatment is given—this is purely for research and knowl…

This study follows 300 babies born early (preterm) and at full term to understand how early birth affects kidney and heart health later in life. Researchers use ultrasound and blood/urine tests to spot early warning signs of kidney disease and high blood pressure. The goal is to …

This study aims to see if giving plant-based foods like fruits, vegetables, and whole grains to food-insecure families can improve their health and nutrition. About 100 families living below the poverty line in Miami will receive these foods and track what they eat. The goal is t…

This study collects information from the medical records of 1,200 people with ALS and related conditions. The goal is to learn more about these diseases and improve future research. Participants must receive care at a clinic that uses Epic electronic health records and speak Engl…

This study uses smartphone apps and brain scans to see how your daily emotions, thoughts, and actions are linked. About 100 adults will answer quick surveys and share location data for four months. The goal is to understand patterns in mood and thinking, not to test a treatment.

This study compares two types of anesthesia (general vs. spinal) for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2,400 participants. The goal is to find out which method leads to b…

This study looks at whether community health workers can help people with non-medical issues that affect health, like finding insurance or a regular doctor. About 900 adults from Florida communities will either get help from a health worker or just read self-help materials. The g…

This study looks at how vaping harms blood vessels, especially in the lungs. Researchers will measure blood flow and vessel function in 90 adults aged 18-40 who vape or are healthy non-vapers. The goal is to find early signs of damage to help prevent future health problems.

This study asks Hispanic/Latinx head and neck cancer survivors about their awareness of lung cancer screening. Researchers will use surveys and interviews to understand what barriers exist. The goal is to improve screening rates in this group. No treatment or medication is involv…

This study looks at whether a blood test that measures endotoxin levels can help predict infections after a type of kidney stone surgery called percutaneous nephrolithotomy (PCNL). Researchers will test blood samples from 150 adults before and after surgery to see if higher endot…

This study follows healthy people who have a family history of ALS and a known genetic mutation that increases their risk. Researchers want to understand what happens in the body before ALS symptoms start, and what factors might trigger the disease. Participants will travel to Mi…

This study uses special lung scans to see how common asthma medications change airflow and blood flow in the lungs. About 40 adults with asthma will take their usual inhaled steroids and a fast-acting rescue inhaler, then get scanned. The goal is to better understand how these me…

This study looks at how much fluid surgeons need to use to fully clean an infected artificial knee joint during a special surgery called DAIR. About 20 adults with knee replacements and infections will take part. Doctors will use a blue dye to track contamination and take photos …

This study looks at how cancer patients use a mobile app called EveryDose to track their oral chemotherapy pills. Researchers want to see if the app helps patients take their medicine as prescribed and if they find it easy to use. About 25 adults with cancer who are starting a ne…

This study looks at whether a slow-release eye injection (Durysta) can reduce eye surface inflammation caused by daily glaucoma eye drops. Researchers will measure a marker of inflammation (caspase-1) in 20 adults with open-angle glaucoma or high eye pressure. The goal is to see …

This study looks at how body composition and diet affect pain and inflammation in people with chronic spinal cord injury. Researchers will measure pain sensitivity and blood markers of inflammation after participants eat a high-fat or moderate-fat meal. The goal is to understand …

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a nutrition and exercise program helps them eat better and move more. About 306 survivors and their healthcare providers will take part. The goal is to see if survivors agr…

This study looks at whether people from underrepresented groups (Black or non-White Hispanic) with heart disease or related conditions can successfully take part in a clinical trial from home using digital tools. Researchers will track how many participants stick with the program…

This study looks at two different ways to check for swallowing problems in people who have had a stroke. The goal is to see which test is better at finding trouble swallowing and the risk of food or liquid going into the lungs. About 50 adults who recently had a stroke will take …

This study looks at why some people who get a new kidney start leaking protein in their urine again soon after the transplant. It focuses on patients with a kidney disease called FSGS. Researchers will test blood and kidney tissue samples before and after the transplant to find t…

This study aims to improve how mild traumatic brain injury (mTBI) is diagnosed and treated. Researchers will use advanced eye, balance, and reaction tests to better identify the injury and predict recovery. They will also test a new, low-risk therapy called passive neurosensory r…

This study looks at whether a simple blood test (ctDNA) can tell doctors early on if chemotherapy is shrinking tumors in people with metastatic pancreatic cancer. Currently, doctors wait about 8 weeks for a scan to check, but this test might give answers in just 4 weeks. About 50…

This study tests whether brain signals can be used to trigger spinal cord stimulation and help people with spinal cord injury move their hands. Three adults with chronic injury will use a brain-computer interface to control the stimulation. The goal is to see if this approach can…

This study looks at how standard radiation treatment for prostate cancer changes MRI and PET scans, and how those changes relate to tumor cells in the blood. About 144 men with prostate cancer will have scans and blood tests before, during, and up to 2.5 years after treatment. Th…

This study looks at how sleep and exercise habits influence the risk of Alzheimer's and dementia. Researchers will track 30 adults who have mild memory or thinking problems. Participants will wear a headband and a Fitbit to measure sleep and heart health, and provide blood and ur…

This study looks at whether unconscious patients with brain injuries show brain activity when they hear music or language. Researchers use a simple bedside EEG test to measure this. They want to see if those who respond are more likely to wake up and recover. The study involves 3…

This study looks at how cannabis use changes brain function in teenagers who also have depression. Researchers will track 280 teens over time, measuring their cannabis use, depression symptoms, and brain activity. The goal is to better understand the relationship between cannabis…

This study aims to see if a specially designed education module helps people with spinal cord injuries learn about their increased risk for heart disease, obesity, and related conditions. Researchers will enroll 250 adults aged 18-70 with spinal cord injuries and measure their kn…

This pilot study looks at whether reducing alcohol and taking probiotics can boost memory and brain function in healthy older adults (ages 65-84) who drink heavily. Participants will get counseling to cut back on drinking and will take either a probiotic or a placebo pill. The st…

This study tests a new MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. Researchers will compare MRI results with tissue samples from 30 adults who are already scheduled for tumor removal. The goal is to improve how doctors track a…

This study looks at how sirolimus, a drug used in transplants, affects the genes inside brain aneurysms. Researchers will compare gene activity in aneurysm tissue and blood samples from 80 adults with unruptured aneurysms. The goal is to learn more about the disease, not to treat…