Can a second injection fix penile curvature?

NCT ID NCT05777031

Ongoing Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a drug called Xiaflex (collagenase clostridium histolyticum) is safe and effective for men with Peyronie's disease who have already tried platelet-rich plasma (PRP) injections. Twelve men with stable penile curvature between 30 and 90 degrees will receive Xiaflex injections into the penile plaque. Researchers will track side effects and measure changes in curvature and symptom bother.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Collagenase clostridium histolyticum (Xiaflex)
What this could lead to: If it works, this could offer a treatment option for men with Peyronie's disease who previously tried PRP without success.
What could go wrong: This is a very small, early-phase study with only 12 participants, so results may not apply to everyone. Side effects like penile bruising or pain are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

male reproductive system disorder Penile Induration Peyronie disease psychosexual disorder reproductive system disorder Sexual Dysfunctions, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENITAL DISEASES, MALE PEYRONIE DISEASE SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL

Contacts and locations

Locations

University of Miami

Miami, Florida, 33136, United States
University of Miami - Desai Sethi Urology Institute

Miami, Florida, 33136, United States

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