Can a second injection fix penile curvature?
NCT ID NCT05777031
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a drug called Xiaflex (collagenase clostridium histolyticum) is safe and effective for men with Peyronie's disease who have already tried platelet-rich plasma (PRP) injections. Twelve men with stable penile curvature between 30 and 90 degrees will receive Xiaflex injections into the penile plaque. Researchers will track side effects and measure changes in curvature and symptom bother.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Collagenase clostridium histolyticum (Xiaflex)
What this could lead to
If it works, this could offer a treatment option for men with Peyronie's disease who previously tried PRP without success.
What could go wrong
This is a very small, early-phase study with only 12 participants, so results may not apply to everyone. Side effects like penile bruising or pain are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Miami
Miami, Florida, 33136, United States
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University of Miami - Desai Sethi Urology Institute
Miami, Florida, 33136, United States