University Of Miami

This study tests a counseling program for people living with HIV who also face mental health challenges or substance use. The program uses one-on-one sessions to help with medication adherence, stress, and other life issues. Researchers will see if participants complete the progr…

This phase 2 trial tests whether adding inhaled corticosteroids to standard COPD treatment improves blood vessel function in the lungs. Thirty adults with COPD, aged 40-80, will take either Bevespi or Bretzri for four weeks. Researchers will measure how well lung blood vessels wi…

This trial tests a stent originally made for heart arteries to treat pseudoaneurysms—bulges or tears—in the carotid or vertebral arteries of the neck. The stent is placed inside the artery to seal the bulge and restore normal blood flow. The study includes people with certain typ…

This study tests whether combining the drug regorafenib with a targeted radiation treatment (Y-90 radioembolization) can control liver cancer that cannot be removed by surgery. About 30 adults with this type of liver cancer will receive the combination therapy. The main goals are…

This study tests whether a drug called Xiaflex (collagenase clostridium histolyticum) is safe and effective for men with Peyronie's disease who have already tried platelet-rich plasma (PRP) injections. Twelve men with stable penile curvature between 30 and 90 degrees will receive…

This phase II trial tests whether using MRI to map the exact location of recurrent prostate cancer after prostatectomy allows doctors to safely deliver a higher radiation dose to the tumor while sparing healthy tissue. The study enrolled 37 men whose PSA levels rose after surgery…

This study tests whether adding the weight-loss drug liraglutide and a lifestyle program to standard catheter ablation can reduce fat around the heart and improve outcomes for people with atrial fibrillation (AF). About 60 adults with AF and a BMI of 27 or higher will take liragl…

This study tested a one-time intravenous infusion of donor stem cells in adults aged 18 to 80 who had a recent (within 9 days) ischemic stroke. The goal was to help the brain heal and improve recovery. While promising, this approach is not a cure and patients still need standard …

This Phase 2 trial tests whether adding daratumumab to a three-drug regimen (carfilzomib, lenalidomide, dexamethasone) works better than the three drugs alone for people newly diagnosed with multiple myeloma. About 310 participants will be randomly assigned to one of the treatmen…

This study tests whether giving an extra-high dose of radiation to the most aggressive parts of prostate tumors, guided by MRI, can better control cancer while reducing side effects. About 164 men with prostate cancer will receive either the standard radiation or the standard plu…

This study tested whether a shorter, more intense radiation schedule (5 sessions) works as well as the standard longer schedule (26 sessions) for men with prostate cancer. The goal was to see if the shorter treatment could control the cancer just as well, based on PSA levels afte…

This study tests whether giving a single high-dose vitamin D pill to patients with low vitamin D levels before hip or knee replacement surgery can reduce complications like infection. About 200 adults with osteoarthritis and vitamin D deficiency will receive 300,000 IU of vitamin…

This study tests whether combining a special MRI analysis (called Habitat Risk Score) with blood and urine tests can more accurately rule out aggressive prostate cancer than the standard MRI reading. About 289 men with elevated PSA or abnormal exams will be enrolled. The goal is …

This study tests whether a health promotion program can prevent anxiety and depression in older Latino adults who are at risk. 240 participants will either join a program with group walks and social sessions led by a community health worker, or attend a healthy lifestyles educati…

This study screens 500 adults in South Florida for H. pylori, a stomach infection that can lead to chronic gastritis, ulcers, and gastric cancer. Those who test positive receive free treatment with a three-drug combination (VOQUEZNA® Triple Pak®) for 14 days. The goal is to see i…

This study screens people in South Florida for H. pylori, a stomach infection that can lead to chronic gastritis, ulcers, and even stomach cancer. Those who test positive receive treatment, and the study compares at-home breath testing versus in-person retesting to confirm the in…

This study tests a program called U-PEACE for high school students who struggle with anxiety, depression, and school challenges. About 72 teens will attend group sessions during school to learn skills for understanding and managing emotions. Researchers will check if the program …

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study tests a wearable device called TracPatch that sticks to the shin after total knee replacement surgery. The patch tracks knee motion, temperature, and steps for six weeks, sending data to doctors. Researchers want to see if this real-time monitoring helps patients regai…

This study tests whether injecting tiny beads into arteries around the knee can reduce pain in people with moderate to severe knee osteoarthritis. The beads block blood flow to the painful area. Nine adults aged 40 to 80 who have not gotten relief from standard treatments are tak…

This study tests ORCHID, an online skills-building program designed to improve mental health and reduce the risk of dropping out of care for aging women with HIV who also have HPV. The program includes 8 online sessions and optional meetings with a navigator. The study aims to se…

This study tests whether a virtual reality (VR) wellness program can help Black women with high blood pressure reduce stress and improve heart health. Sixty Black women in South Florida will either use a five-week VR program or receive standard educational materials. Researchers …

This phase 2 trial tests whether injecting platelet-rich plasma (PRP) into the vulva and vagina can improve symptoms of genitourinary syndrome of menopause (GSM) in breast cancer survivors. GSM causes dryness, burning, and pain, often worsened by cancer treatments. The study enro…

This study aimed to see if a simple mindfulness breathing exercise could improve health and quality of life in people with spinal cord injury. Participants would have done a 10-15 minute guided breathing session three times a week for a month. However, the trial was withdrawn bef…

This study looks at whether a simple home exercise program can improve strength, endurance, and quality of life for people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will have 86 adults with HS follow a video-guided exercise routine 3-4 days a week.…

This study tests whether a special 1726nm laser can safely reduce the painful bumps and inflammation caused by hidradenitis suppurativa (HS). Eight adults with mild to moderate HS will receive laser treatment on affected areas like armpits or groin. The main goal is to see if at …

This study looks at two procedures—prostate artery embolization (PAE) and holmium laser enucleation (HoLEP)—to see which better eases urinary symptoms caused by an enlarged prostate. It involves 45 men aged 50 or older with prostates larger than 80 grams. The main goal is to meas…

This study tests whether a group-based behavioral program called Horizons can improve quality of life and coping skills in adults with chronic graft-versus-host disease (cGVHD), a common complication after stem cell transplant. The program involves 8 weekly video sessions with a …

This study is testing whether a mobile app called Horizons can help adults with chronic graft-versus-host disease (a long-term complication after a bone marrow transplant) manage their symptoms and improve their quality of life. Twenty participants will use the app for about six …

This study looks at whether nutrition education and one-on-one counseling can reduce chronic pain in people with spinal cord injury. Thirty adults will attend monthly sessions for four months, either in person or online. Researchers will measure changes in pain intensity and nerv…

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments …

This study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…

This study enrolls people with ALS and related disorders, as well as healthy volunteers, to track biological markers (biomarkers) in urine, blood, and spinal fluid. The goal is to better understand how these markers change over time, which could help design more effective future …

This study looks at whether common baby items, such as bouncers and carriers, can help healthy infants develop better. Researchers will observe 100 mothers and their full-term babies, measuring things like eye tracking, crying, smiling, and parent-child interaction. The goal is t…

This study gathers information from 1,200 pregnant people carrying twins that share a placenta (monochorionic twins). Researchers track complications like preterm birth and infant death to better understand these high-risk pregnancies. No new treatments are tested; the goal is to…

This study tests whether AI-generated messages can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will view different messages. Researchers will measure changes in their beliefs about canc…

This study looks at blood samples from 400 people with and without HIV to understand how aging and HIV infection change the body's immune response to the flu vaccine. Researchers will measure antibody levels and immune cell types to see who responds well to the vaccine and who do…

This study looks at whether a fear-inducing virtual reality (VR) experience can change how much empathy people feel. About 110 young adults (ages 18-25) will either experience a scary VR scenario, like walking a plank high above a city, or a neutral one. Researchers will measure …

This study looks at how opioid use affects the immune system's response to the flu vaccine in people with and without HIV. Researchers will analyze blood samples from 400 participants to measure antibody levels and immune cell activity. The goal is to understand why opioid users …

This study looks at people with early ALS who still have some unaffected body areas. Researchers want to find the very first signs of the disease spreading. By observing 100 participants over time, they hope to learn how ALS starts and progresses, which could help with earlier di…

This study looks at whether a blood test that tracks tumor DNA (ctDNA) can help doctors switch treatments earlier in people with metastatic breast cancer. The goal is to see if acting on a molecular signal of progression, before symptoms or scans show it, can keep the cancer unde…

This study aims to identify the bacteria and fungi living in the urinary tract of people with calcium oxalate kidney stones or kidney cancer. Researchers will compare these microbial communities to those in healthy volunteers. The goal is to better understand how these tiny organ…