Can a diabetes drug help stop AFib after ablation?
NCT ID NCT03856632
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the weight-loss drug liraglutide and a lifestyle program to standard catheter ablation can reduce fat around the heart and improve outcomes for people with atrial fibrillation (AF). About 60 adults with AF and a BMI of 27 or higher will take liraglutide for 3 months before and 6 months after the procedure, along with diet and exercise guidance. The goal is to see if shrinking heart fat can stabilize heart rhythm and reduce the need for repeat procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Liraglutide (a weight-loss drug) plus a lifestyle program (weight management, exercise, and cholesterol control)
- What this could lead to
- If it works, this could point toward a way to reduce heart fat and make atrial fibrillation less likely to return after a standard ablation procedure.
- What could go wrong
- This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. The drug can cause nausea and other side effects, and the added benefit over ablation alone is unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ATRIAL FIBRILLATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Miami
Miami, Florida, 33136, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A tiny neck implant could catch Stroke-Causing clots before they reach the brain
- Could a new injection tame atrial fibrillation?
- Which blood thinner is safer for heart patients? a Head-to-Head test
- Can a cholesterol drug keep atrial fibrillation at bay after ablation?
- Can a One-Two punch fix a leaky heart valve and restore normal rhythm?
- Could a guided Self-Care plan tame atrial Fibrillation's return?