Opioid use may weaken flu shots in HIV patients, study suggests
NCT ID NCT04304768
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how opioid use affects the immune system's response to the flu vaccine in people with and without HIV. Researchers will analyze blood samples from 400 participants to measure antibody levels and immune cell activity. The goal is to understand why opioid users may have weaker immune defenses after vaccination.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fluzone Quadrivalent (influenza vaccine)
- What this could lead to
- If successful, this could reveal how opioids impair vaccine effectiveness in people with HIV, guiding better vaccination strategies.
- What could go wrong
- This is an observational study focused on immune markers, not a treatment trial. Results may not lead to direct clinical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Miami
Miami, Florida, 33136, United States
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