Opioid use may weaken flu shots in HIV patients, study suggests
NCT ID NCT04304768
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how opioid use affects the immune system's response to the flu vaccine in people with and without HIV. Researchers will analyze blood samples from 400 participants to measure antibody levels and immune cell activity. The goal is to understand why opioid users may have weaker immune defenses after vaccination.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Fluzone Quadrivalent (influenza vaccine)
What this could lead to
If successful, this could reveal how opioids impair vaccine effectiveness in people with HIV, guiding better vaccination strategies.
What could go wrong
This is an observational study focused on immune markers, not a treatment trial. Results may not lead to direct clinical changes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Miami
Miami, Florida, 33136, United States