Blood test may help doctors switch cancer treatment earlier
NCT ID NCT05826964
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether a blood test that tracks tumor DNA (ctDNA) can help doctors switch treatments earlier in people with metastatic breast cancer. The goal is to see if acting on a molecular signal of progression, before symptoms or scans show it, can keep the cancer under control longer. About 24 participants will be randomly assigned to switch therapy early based on ctDNA levels or wait for standard signs of progression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Aromatase inhibitor (AI) or selective estrogen receptor degrader (SERD) plus a CDK4/6 inhibitor
- What this could lead to
- If successful, this could show that using a blood test to detect early molecular changes allows doctors to switch treatments sooner, potentially keeping metastatic breast cancer under control for longer.
- What could go wrong
- This is a small, early-phase study (24 people) testing a monitoring strategy, not a new drug. The approach may not improve outcomes or could lead to unnecessary treatment switches.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Miami
Miami, Florida, 33136, United States
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