ER POSITIVE BREAST CANCER
Clinical trials for ER POSITIVE BREAST CANCER explained in plain language.
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Blood test catches cancer early: new drug aims to stop spread
Disease control Recruiting nowThis Phase 3 trial tests whether elacestrant, a new hormone therapy, can prevent distant metastasis better than standard hormone therapies in 220 patients with ER+/HER2- breast cancer whose blood tests show signs of cancer DNA (ctDNA) but no visible spread. Participants are rando…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: European Organisation for Research and Treatment of Cancer - EORTC • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Can a smart drug cross the Blood-Brain barrier to attack breast cancer metastases?
Disease control Recruiting nowThis phase 2 trial is testing whether the investigational drug datopotamab deruxtecan (Dato-DXd) can safely and effectively treat HER2-negative breast cancer that has spread to the brain. The study enrolls adults with metastatic breast cancer who have brain metastases that are ei…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Nancy Lin, MD • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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New hope for advanced breast cancer: phase 3 trial launches
Disease control Recruiting nowThis phase 3 trial is testing a new drug called palazestrant (OP-1250) combined with ribociclib against the standard letrozole plus ribociclib for people with ER+, HER2- advanced breast cancer who haven't had prior treatment. About 1,000 participants will be randomly assigned to …
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: Olema Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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New drug cocktail aims to wipe out breast cancer before surgery
Disease control Recruiting nowThis phase 2 trial is testing whether giving a combination of three drugs—neratinib, an aromatase inhibitor (letrozole or anastrozole), and trastuzumab—before surgery can completely eliminate invasive breast cancer in postmenopausal women with ER-positive, HER2-positive breast ca…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Ruth O'Regan • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Promising combo aims to stall advanced breast cancer
Disease control Recruiting nowThis study tests whether adding everolimus to elacestrant can help people with a certain type of advanced breast cancer (ER+/HER2- with an ESR1 mutation) live longer without their cancer getting worse. About 240 adults whose cancer has stopped responding to standard hormone thera…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE3 • Sponsor: MedSIR • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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New hope for breast cancer patients when first treatment fails
Disease control Recruiting nowThis study tests a combination of two drugs, fulvestrant and abemaciclib, for people with a certain type of advanced breast cancer (ER-positive, HER2-negative) that has stopped responding to a first-line treatment called a CDK4/6 inhibitor. The goal is to see if taking a break fr…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New hope for advanced breast cancer: drug combo trial opens
Disease control Recruiting nowThis early-phase study tests a new drug called OP-1250 (palazestrant) combined with other targeted therapies in people with advanced or metastatic ER-positive, HER2-negative breast cancer. The main goals are to find safe doses and check for side effects. About 190 adults will joi…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE1 • Sponsor: Olema Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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New scan could spot hidden breast cancer spread
Diagnosis Recruiting nowThis study compares two PET scan tracers—standard 18F-FDG and newer 68Ga-FAPI-46—in 20 women with ER-positive breast cancer. The goal is to see if the new tracer finds more cancer lesions, especially where the standard one may miss them. Better detection could lead to more accura…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: PHASE2 • Sponsor: Maastricht University Medical Center • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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New app aims to help breast cancer patients stick with Long-Term treatment
Knowledge-focused Recruiting nowThis study is testing a new web and mobile app called SHIELD, designed to support women with hormone receptor-positive breast cancer who are on long-term hormone therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women will particip…
Matched conditions: ER POSITIVE BREAST CANCER
Phase: NA • Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC