New hope for breast cancer patients: elacestrant targets hidden relapse before tumors spread

NCT ID NCT05512364

Recruiting now Disease control Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Source: ClinicalTrials.gov ↗

First seen May 15, 2026 · Last updated May 15, 2026

Summary

This study tests a drug called elacestrant against standard hormone therapy in 220 people with ER+/HER2- breast cancer whose blood tests show signs of cancer returning (ctDNA) but no visible spread. The goal is to see if elacestrant can delay or prevent distant metastasis. Participants continue treatment as needed, so this is about controlling the disease, not a cure.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

AUSL Romagna - AUSL Della Romagna - Infermi Hospital -Rimini
RECRUITING

Rimini, 47923, Italy
AZ Delta - Campus Rumbeke
RECRUITING

Roeselare, 8800, Belgium
AZ Groeninge Kortrijk - Campus Kennedylaan
RECRUITING

Kortrijk, 8500, Belgium
Agios Loukas Clinic (St Lukes)
RECRUITING

Thessaloniki, Greece
Althaia Xarxa Assistencial Universitaria De Manresa Fundacio Privada
RECRUITING

Manresa, 08242, Spain
Amsterdam UMC - locatie VUMC
RECRUITING

Amsterdam, 1081 HV, Netherlands
Azienda Ospedaliera Papa Giovanni XXIII
RECRUITING

Bergamo, 24127, Italy
Azienda Ospedaliera Universitaria "Federico II"
RECRUITING

Naples, 80131, Italy
Azienda Ospedaliera Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
Azienda Ospedaliero - Universitaria Policlinico di Modena
RECRUITING

Modena, Italy
Azienda Ospedaliero-Universitaria di Parma
RECRUITING

Parma, 43126, Italy
Azienda USL IRCCS Di Reggio Emilia - Maria Nuova
RECRUITING

Reggio Emilia, 42100, Italy
Azienda USL IRCCS Di Reggio Emilia Guastalla
RECRUITING

Guastalla, 42016, Italy
Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital
RECRUITING

Legnano, 37045, Italy
Bank Of Cyprus Oncology Centre
RECRUITING

Stróvolos, 2006, Cyprus
Beacon Hospital
RECRUITING

Dublin, D18 AK68, Ireland
Buergerspital Solothurn -Brustzentrum
RECRUITING

Solothurn, 4500, Switzerland
Busch MCZ GmbH
RECRUITING

Mühlhausen, 99974, Germany
CHU Helora Pole Hospitalier Jolimont - Hopital Jolimont
RECRUITING

Haine-Saint-Paul, 7100, Belgium
CHU Site Sainte-Elisabeth-UCL Namur
RECRUITING

Namur, 5000, Belgium
CHU de Limoges - Hopital Dupuytren
RECRUITING

Limoges, 87042, France
CHU de Lyon - Hopital De La Croix Rousse
RECRUITING

Lyon, 69004, France
CHU de Lyon - Hopital Femme Mere Enfant
RECRUITING

Bron, 69677, France
CHU de Lyon - Hopital Lyon Sud
RECRUITING

Pierre-Bénite, 69495, France
CHU de Lyon - Hopital Lyon Sud
RECRUITING

Pierre-Bénite, France
CHU de Lyon - Hopital de la Croix Rousse
RECRUITING

Lyon, France
CHU de Toulouse - Institut Claudius Regaud - IUCT oncopole
RECRUITING

Toulouse, 31059, France
Centre Hospitalier - Boulogne Sur Mer
RECRUITING

Boulogne-sur-Mer, 62321, France
Centre Hospitalier Regional Verviers
RECRUITING

Verviers, 4800, Belgium
Centre de Radiotherapie Pierre Curie
RECRUITING

Beuvry, 62660, France
Centro Di Riferimento Oncologico
RECRUITING

Aviano, 33081, Italy
Centro Hospitalar Vila Nova Gaia/Espinho
RECRUITING

Vila Nova de Gaia, Portugal
Clinique Belharra-Ramsay Sante
RECRUITING

Bayonne, 64100, France
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A.
RECRUITING

Athens, 15123, Greece
Evangelisches Krankenhaus -Bergisch Gladbach
RECRUITING

Bergisch Gladbach, 51465, Germany
Flevoziekenhuis Stichting
RECRUITING

Almere Stad, 1315 RA, Netherlands
GRN Klinik Weinheim
RECRUITING

Weinheim, Germany
Gemeinschaftspraxis Augsburg
RECRUITING

Augsburg, 86150, Germany
Gemeinschaftspraxis Dr. Pourfard / Dr. Uleer
RECRUITING

Hildesheim, 31134, Germany
General University Hospital of Larissa
RECRUITING

Larissa, 41110, Greece
German Oncology Center
RECRUITING

Limassol, 4108, Cyprus
Grand Hopital de Charleroi - Site Notre Dame
RECRUITING

Charleroi, 6000, Belgium
HELIOS Kliniken - Helios Klinikum Wuppertal - Klin. Univ. Witten / Herdecke
RECRUITING

Wuppertal, 42283, Germany
Haaglanden Medisch Centrum
RECRUITING

Leidschendam, 2262 BA, Netherlands
Hamatologische Onkologische Praxis Im Medicum
RECRUITING

Bremen, 28209, Germany
Hopital Universitaire Brugmann
RECRUITING

Brussels, Belgium
Hopital de Douai- Centre Leonard de Vinci
RECRUITING

Dechy, 59187, France
Hospital CUF Tejo
RECRUITING

Lisbon, Portugal
Hospital Clinico Universitario - Virgen De La Arrixaca
RECRUITING

El Palmar, 30120, Spain
Hospital Clinico Universitario De Valencia
RECRUITING

Valencia, 46010, Spain
Hospital General Universitario Doctor Balmis
RECRUITING

Alicante, 03010, Spain
Hospital Quironsalud Sagrado Corazon
RECRUITING

Seville, 41013, Spain
Hospital Sant Joan de Reus
RECRUITING

Reus, 43204, Spain
Hospital Universitari Arnau De Vilanova
RECRUITING

Lleida, 25196, Spain
Hospital Universitari Son Espases
RECRUITING

Palma de Mallorca, 07010, Spain
Hospital Universitario 12 De Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Clinico San Cecilio
RECRUITING

Granada, 18016, Spain
Hospital Universitario De Cruces
RECRUITING

Barakaldo, 48903, Spain
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, Spain
Hospital Universitario Virgen De La Macarena
RECRUITING

Seville, 41071, Spain
Hospital Universitario Virgen De Las Nieves
RECRUITING

Granada, 18014, Spain
Hospital Universitario Y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario de Navarra
RECRUITING

Pamplona, 31008, Spain
Hospitales HM Sanchinarro-CIOCC
RECRUITING

Madrid, 28050, Spain
ICO Girona - Hospital Doctor Josep Trueta
RECRUITING

Girona, 17007, Spain
ICO L'Hospitalet - Hospital Duran i Reynals
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
IRCCS Azienda Policlinico San Martino
RECRUITING

Genova, 16132, Italy
IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
RECRUITING

Meldola, 47014, Italy
Ikazia Ziekenhuis
RECRUITING

Rotterdam, 3083, Netherlands
Institut Curie - Hopital de Paris
RECRUITING

Paris, France
Institut Curie - l'Hopital de St Cloud
RECRUITING

Saint-Cloud, 92210, France
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Instituto Europeo di Oncologia
RECRUITING

Milan, Italy
Istituti Clinici Scientifici Maugeri
RECRUITING

Pavia, 27100, Italy
Kantonsspital Frauenfeld- Breast Unit Thurgau
RECRUITING

Frauenfeld, 8500, Switzerland
Karolinska University Hospital, location Solna
RECRUITING

Stockholm, 17164, Sweden
Klinikum Ernst von Bergmann gemeinnützige GmbH
RECRUITING

Potsdam, 14467, Germany
Klinikum Kassel Gmbh
RECRUITING

Kassel, 34125, Germany
Klinikum Nuernberg- Standort Nord
RECRUITING

Nuremberg, 90419, Germany
Klinikum rechts der Isar München
RECRUITING

München, Germany
MVM MbH -Onkologie UnterEms, Leer-Papenburg-Emden
RECRUITING

Leer, 26789, Germany
Marienhospital Bottrop gGmbH
RECRUITING

Bottrop, 46236, Germany
Mater Misericordia University Hospital
RECRUITING

Dublin, Ireland
Mater Private Hospital
RECRUITING

Dublin, D07 WKW8, Ireland
Mathias Spital Rheine
RECRUITING

Rheine, Germany
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
Ospedale Alessandro Manzoni
RECRUITING

Lecco, 23900, Italy
Ospedale P. Pederzoli Casa Di Cura Privata
RECRUITING

Peschiera del Garda, Italy
Polyclinique De Gentilly - Centre d'Oncologie
RECRUITING

Nancy, 54100, France
Rems-Murr-Kliniken gGmbH
RECRUITING

Winnenden, Germany
Rijnstate Hospital
RECRUITING

Arnhem, 6815, Netherlands
San Maria della Misericordia Hospital
RECRUITING

Perugia, 06129, Italy
Sint Antonius - St Antonius Ziekenhuis Utrecht
RECRUITING

Utrecht, 3543, Netherlands
Skane University Hospital
RECRUITING

Lund, Sweden
Societe de Recherche Oncologique Clinique 37
RECRUITING

Chambray-lès-Tours, 31170, France
Sodra Alvsborgs Sjukhus - Vastra Gotalandsregionen
RECRUITING

Borås, 50182, Sweden
St Elisabeth-Krankenhaus
RECRUITING

Cologne, 50935, Germany
St. James'S Hospital
RECRUITING

Dublin, D08 NHY1, Ireland
U.Z. Leuven - Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Univ. of Florence -Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Universitaetsklinikum Aachen AOR - Medizinische Fakultaet der RWTH
RECRUITING

Aachen, 52074, Germany
Universitaetsklinikum Carl Gustav Carus (TUD)
RECRUITING

Dresden, 01307, Germany
Universitaetsklinikum Tuebingen-calwerstrasse
RECRUITING

Tübingen, 72076, Germany
Universitaetsklinikum Ulm-Michelsberg
RECRUITING

Ulm, 89075, Germany
University Hospital Virgen del Rocio
RECRUITING

Seville, 41013, Spain
University Hospital Waterford
RECRUITING

Waterford, Ireland
University Hospital of Cagliari Duilio Casula Hospital Unit (Policlinico)
RECRUITING

Monserrato, 09042, Italy
VieCuri - Medisch Centrum voor Noord-Limburg - Locatie Venlo
RECRUITING

Venlo, 5912, Netherlands

Conditions

Explore the condition pages connected to this study.

ER-POSITIVE BREAST CANCER HER2-NEGATIVE BREAST CANCER STAGE IIB BREAST CANCER STAGE III BREAST CANCER