New pill combo aims to delay chemo in advanced breast cancer

NCT ID NCT07647328

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This phase 3 trial is testing two oral drugs, camizestrant and ribociclib, as a first treatment for people with ER-positive, HER2-negative advanced breast cancer. The goal is to see if the combination can delay the need for next cancer therapy. About 150 participants will take the pills daily until their cancer progresses or side effects become too much.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: camizestrant and ribociclib (oral tablets)
What this could lead to: If successful, this combination could offer a new first-line treatment option that delays the need for further chemotherapy in advanced breast cancer.
What could go wrong: This is a single-arm, open-label study without a placebo group, so results may be less definitive. Side effects from the drug combination are possible, and the trial is still recruiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast disorder breast neoplasm estrogen-receptor positive breast cancer hormone receptor-positive breast cancer neoplasm Neoplasm Metastasis Neoplasms by Site

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ER-POSITIVE HER2-NEGATIVE BREAST CANCER

Contacts and locations

Locations

Research Site
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Duarte, California, 91010, United States
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Palo Alto, California, 94304, United States
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RECRUITING

Marietta, Georgia, 30060, United States
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Evanston, Illinois, 60201, United States
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Edgewood, Kentucky, 41017, United States
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Louisville, Kentucky, 40202, United States
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Reno, Nevada, 89502, United States
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Sioux Falls, South Dakota, 57105, United States
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Nashville, Tennessee, 37204, United States
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Fort Worth, Texas, 76104, United States
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Kingwood, Texas, 77339, United States
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Midlothian, Virginia, 23114, United States
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Angers, 49933, France
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Bayonne, 64109, France
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Bobigny, 93000, France
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Caen, 14000, France
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Chambray-lès-Tours, 37170, France
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Grenoble, 38043, France
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Montpellier, 34070, France
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Nancy, 54100, France
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Nîmes, 30029, France
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Paris, 75014, France
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Pierre-Bénite, 69310, France
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Valenciennes, 59300, France
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Vandœuvre-lès-Nancy, 54519, France
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Villejuif, 94805, France
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Berlin, 13125, Germany
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Düsseldorf, 40235, Germany
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Erlangen, 91054, Germany
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Freiburg im Breisgau, 79110, Germany
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Mönchengladbach, 41061, Germany
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München, 81675, Germany
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Paderborn, 33098, Germany
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Trier, 54290, Germany
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Velbert, 42551, Germany
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Aviano, 33081, Italy
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Bergamo, 24127, Italy
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Genova, 16132, Italy
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Milan, 20127, Italy
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Naples, 80131, Italy
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Gdansk, 80-952, Poland
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Konin, 62-500, Poland
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Krakow, 30-688, Poland
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Lodz, 90-302, Poland
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Lublin, 20-090, Poland
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Poznan, 61-485, Poland
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Przemyśl, 37-700, Poland
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Wroclaw, 53-413, Poland
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Cheonan-si, 31151, South Korea
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SUSPENDED

Daegu, 42415, South Korea
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Goyang-si, 10408, South Korea
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Hwasun-eup, 58128, South Korea
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Incheon, 405-760, South Korea
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Seongbuk-Gu, 02841, South Korea
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Seongnam-si, 13520, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 07985, South Korea
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Seoul, 3722, South Korea
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Songpa-gu, 05505, South Korea
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SUSPENDED

Suwon, 16499, South Korea
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Badajoz, 06080, Spain
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Badalona, 08916, Spain
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Barcelona, 08041, Spain
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Burgos, 9006, Spain
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Donostia / San Sebastian, 20014, Spain
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Huelva, 21005, Spain
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Jaén, 23007, Spain
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Las Palmas de Gran Canaria, 35016, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Murcia, 30008, Spain
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Oviedo, 33011, Spain
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Palma de Mallorca, 07198, Spain
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Pontevedra, 36312, Spain
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Pozuelo de Alarcón, 28223, Spain
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Santander, 39008, Spain
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Toledo, 45007, Spain
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Zaragoza, 50009, Spain
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Basel, 4031, Switzerland
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Liestal, CH-4410, Switzerland
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Rennaz, 1847, Switzerland
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Abu Dhabi, 11241, United Arab Emirates
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Al Ain City, 00000, United Arab Emirates
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Dubai, 505004, United Arab Emirates
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Mohammed Bin Zayed City, 92510, United Arab Emirates

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