BREAST CANCER BREAKTHROUGH? new study lets patients choose chemo-free treatment

NCT ID NCT06953882

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people with a common type of breast cancer (ER-positive, HER2-negative) that has a moderate to high risk of coming back based on tumor size and lymph node involvement, but a low genetic risk score. Instead of chemotherapy after surgery, participants can choose to take a combination of ribociclib (a targeted pill) and optimized hormone therapy. The main goal is to see how many people can stay on ribociclib for a full year without stopping due to side effects or other reasons. The study is currently recruiting 140 participants.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06511, United States

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