Promising combo aims to stall advanced breast cancer

NCT ID NCT06382948

Recruiting now Disease control Sponsor: MedSIR Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding everolimus to elacestrant can help people with a certain type of advanced breast cancer (ER+/HER2- with an ESR1 mutation) live longer without their cancer getting worse. About 240 adults whose cancer has stopped responding to standard hormone therapy and CDK4/6 inhibitors will receive either the drug combo or elacestrant alone. The goal is to see if the combination delays disease progression.

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Conditions

The condition(s) this trial relates to.

breast cancer estrogen-receptor positive breast cancer Her2-receptor negative breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER ER POSITIVE BREAST CANCER ESR1 GENE MUTATION HER2-NEGATIVE BREAST CANCER

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

251 Air Force General Hospital
RECRUITING

Athens, Greece
AOU Policilinico Modena
RECRUITING

Modena, Italy
APHP Tenon
NOT_YET_RECRUITING

Paris, France
Aou Careggi
RECRUITING

Florence, Italy
Aretaeio Hospital
RECRUITING

Athens, Greece
Attikon University Hospital
RECRUITING

Athens, Greece
Azienda Ospedaliero- Universitaria Maggiore Della Carita
RECRUITING

Novara, Italy
Azienda Ospedaliero-Universitaria (AOU) di Cagliari
NOT_YET_RECRUITING

Cagliari, Italy
Barts Health NHS Trust
RECRUITING

London, United Kingdom
CHU Lyon Sud
RECRUITING

Lyon, France
CHU Saint Etienne
RECRUITING

Saint-Priest-en-Jarez, France
Catarina Pesquisa Clínica - Neoplasias Litoral
NOT_YET_RECRUITING

Itajaí, Brazil
Centre Georges François Leclerc
RECRUITING

Dijon, France
Centre Hospitalier de Limoges
RECRUITING

Limoges, France
Centro Oncológico de Galicia
RECRUITING

A Coruña, Spain
Cliniche Gavazzeni
NOT_YET_RECRUITING

Bergamo, Italy
Complejo Hospitalario Universitario de Santiago (CHUS)
RECRUITING

A Coruña, Spain
Complejo Hospitalario de Jaén
RECRUITING

Jaén, Spain
Consorci Hospital General Universitari de València
RECRUITING

Valencia, Spain
EU Interbalkan Medical Center
RECRUITING

Thessaloniki, Greece
Fondazione Pascale
NOT_YET_RECRUITING

Naples, Italy
General University Hospital Prague
RECRUITING

Prague, Czechia
General University Hospital of Patras
RECRUITING

Pátrai, Greece
Genesis Cancer Care UK
RECRUITING

Waterlooville, United Kingdom
Genesis Care Oxford
RECRUITING

Oxford, United Kingdom
Hospital Arnau de Vilanova de Valencia
RECRUITING

Valencia, Spain
Hospital Beata María Ana
RECRUITING

Madrid, Spain
Hospital Cachoeiro de Itapemirim
NOT_YET_RECRUITING

Cachoeiro de Itapemirim, Brazil
Hospital Clínic i Provincial de Barcelona
RECRUITING

Barcelona, Spain
Hospital Clínico Universitario Lozano Blesa
RECRUITING

Zaragoza, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

Murcia, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Spain
Hospital General Universitario Dr. Balmis (Alicante)
RECRUITING

Alicante, Spain
Hospital Provincial de Castellón
RECRUITING

Castellon, Spain
Hospital Quirónsalud Sagrado Corazón
RECRUITING

Seville, Spain
Hospital San Pedro de Alcántara
RECRUITING

Cáceres, Spain
Hospital Universitari Dexeus
RECRUITING

Barcelona, Barcelona, Spain
Hospital Universitari Sant Joan de Reus
RECRUITING

Tarragona, Spain
Hospital Universitari Son Espases
RECRUITING

Palma de Mallorca, Spain
Hospital Universitari Vall D'Hebron
RECRUITING

Barcelona, Spain
Hospital Universitario Arnau de Vilanova de Lleida
RECRUITING

Lleida, Spain
Hospital Universitario Clínico San Cecilio de Granada
RECRUITING

Granada, Spain
Hospital Universitario Doce de Octubre
RECRUITING

Madrid, Spain
Hospital Universitario Insular de Gran Canaria
RECRUITING

Las Palmas de Gran Canaria, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, Spain
Hospital Universitario La Ribera - Alzira
RECRUITING

Valencia, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Valdecilla, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Madrid, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Spain
Hospital Universitario San Juan de Alicante
RECRUITING

Alicante, Spain
Hospital Universitario Sanchinarro-START-CIOCC
RECRUITING

Madrid, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Spain
Hospital Universitario de Basurto
RECRUITING

Bilbao, Spain
Hospital Universitario de Burgos
RECRUITING

Burgos, Spain
Hospital Universitario de Canarias
RECRUITING

Santa Cruz de Tenerife, Spain
Hospital Universitario de León
RECRUITING

León, Spain
Hospital del Mar
RECRUITING

Barcelona, Spain
Hospital prive des Cotes d'Amor
RECRUITING

Plérin, France
Hospitalario Universitario de Navarra
RECRUITING

Pamplona, Spain
Hämatologie-Onkologie im Zentrum MVZ GmbH
NOT_YET_RECRUITING

Augsburg, Germany
IRCCS Ospedale Policlinico San Martino
NOT_YET_RECRUITING

Genova, Italy
IRCCS San Gerardo
NOT_YET_RECRUITING

Monza, Italy
IUCT Oncopole
RECRUITING

Toulouse, France
Institut Bergonié Bordeaux
NOT_YET_RECRUITING

Bordeaux, France
Institut Català d' Oncologia Badalona (ICO)
RECRUITING

Badalona, Spain
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, France
Institute de Cancerologie de Lorraine - Nancy
RECRUITING

Vandœuvre-lès-Nancy, France
Instituto Europeo di Oncologia
RECRUITING

Milan, Italy
Klinikum Worms - Frauenklinik
RECRUITING

Worms, Germany
MD Anderson Cancer Center Madrid
RECRUITING

Madrid, Spain
MVZ II der Niels Stensen Kliniken
RECRUITING

Georgsmarienhütte, Germany
MVZ Klinikum Aschaffenburg
NOT_YET_RECRUITING

Aschaffenburg, Germany
Masaryk Memorial Cancer Institute
RECRUITING

Brno, Czechia
Medical University of Vienna
NOT_YET_RECRUITING

Vienna, Austria
Medizinische Universität Innsbruck
RECRUITING

Innsbruck, Austria
Metropolitan General Hospital 4th department
RECRUITING

Athens, Greece
Metropolitan Hospital Greece 1st department
RECRUITING

Piraeus, Greece
Multiscan Nemocnice Horovice
RECRUITING

Hořovice, Czechia
NOB Ondina
NOT_YET_RECRUITING

Salvador, Brazil
Oncologia Medica AUSL Piacenza
RECRUITING

Piacenza, Italy
Ordensklinikum Linz Barmherzige Schwestern
RECRUITING

Linz, Austria
Ordination Priv.-Doz. Dr. Michael Hubalek
RECRUITING

Schwaz, Austria
Ospedali Riuniti Livorno
RECRUITING

Livorno, Italy
Policlinico A. Gemelli IRCCS
NOT_YET_RECRUITING

Roma, Italy
Polyclinique Bordeaux Nord Aquitaine
RECRUITING

Bordeau, France
Royal Cornwall Hospital NHS Trust
RECRUITING

Truro, United Kingdom
Royal Surrey County Hospital
RECRUITING

Surrey Quays, United Kingdom
Städtisches Klinikum Dessau
NOT_YET_RECRUITING

Dessau, Germany
Tacchini Instituto de Pesquisa
NOT_YET_RECRUITING

Bento Gonçalves, Brazil
Tomas Bata Regional Hospital in Zlin
RECRUITING

Zlín, Czechia
UPCO - Hospital de Clinicas de Porto Alegre
NOT_YET_RECRUITING

Porto Alegre, Brazil
University General Hospital Alexandroupoli
RECRUITING

Alexandroupoli, Greece
University General Hospital of Heraklion
RECRUITING

Heraklion, Greece
University General Hospital of Larissa
RECRUITING

Larissa, Greece
University Hospital Olomouc
NOT_YET_RECRUITING

Olomouc, Czechia
Universitätsklinikum Dusseldorf
NOT_YET_RECRUITING

Düsseldorf, Germany
Universitätsklinikum Essen
NOT_YET_RECRUITING

Essen, Germany
Western General Hospital
NOT_YET_RECRUITING

Edinburgh, United Kingdom

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