Promising combo targets Hard-to-Treat breast cancer

NCT ID NCT06382948

Recruiting now Disease control Sponsor: MedSIR Source: ClinicalTrials.gov ↗

First seen Jan 06, 2026 · Last updated May 12, 2026 · Updated 15 times

Summary

This study tests whether adding everolimus to elacestrant works better than elacestrant alone for people with a certain type of advanced breast cancer (ER+/HER2- with an ESR1 mutation). About 240 adults whose cancer has worsened after standard hormone therapy and CDK4/6 inhibitors will take part. The main goal is to see how long the cancer stays under control with the combination.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

251 Air Force General Hospital
RECRUITING

Athens, Greece

Contact
AOU Policilinico Modena
RECRUITING

Modena, Italy

Contact
APHP Tenon
NOT_YET_RECRUITING

Paris, France

Contact
Aou Careggi
RECRUITING

Florence, Italy

Contact
Aretaeio Hospital
RECRUITING

Athens, Greece

Contact
Attikon University Hospital
RECRUITING

Athens, Greece

Contact
Azienda Ospedaliero- Universitaria Maggiore Della Carita
RECRUITING

Novara, Italy

Contact
Azienda Ospedaliero-Universitaria (AOU) di Cagliari
NOT_YET_RECRUITING

Cagliari, Italy

Contact
Barts Health NHS Trust
RECRUITING

London, United Kingdom

Contact
CHU Lyon Sud
RECRUITING

Lyon, France

Contact
CHU Saint Etienne
RECRUITING

Saint-Priest-en-Jarez, France

Contact
Catarina Pesquisa Clínica - Neoplasias Litoral
NOT_YET_RECRUITING

Itajaí, Brazil

Contact
Centre Georges François Leclerc
RECRUITING

Dijon, France

Contact
Centre Hospitalier de Limoges
RECRUITING

Limoges, France

Contact
Centro Oncológico de Galicia
RECRUITING

A Coruña, Spain

Contact
Cliniche Gavazzeni
NOT_YET_RECRUITING

Bergamo, Italy

Contact
Complejo Hospitalario Universitario de Santiago (CHUS)
RECRUITING

A Coruña, Spain

Contact
Complejo Hospitalario de Jaén
RECRUITING

Jaén, Spain

Contact
Consorci Hospital General Universitari de València
RECRUITING

Valencia, Spain

Contact
EU Interbalkan Medical Center
RECRUITING

Thessaloniki, Greece

Contact
Fondazione Pascale
NOT_YET_RECRUITING

Naples, Italy

Contact
General University Hospital Prague
RECRUITING

Prague, Czechia

Contact
General University Hospital of Patras
RECRUITING

Pátrai, Greece

Contact
Genesis Cancer Care UK
RECRUITING

Waterlooville, United Kingdom

Contact
Genesis Care Oxford
RECRUITING

Oxford, United Kingdom

Contact
Hospital Arnau de Vilanova de Valencia
RECRUITING

Valencia, Spain

Contact
Hospital Beata María Ana
RECRUITING

Madrid, Spain

Contact
Hospital Cachoeiro de Itapemirim
NOT_YET_RECRUITING

Cachoeiro de Itapemirim, Brazil

Contact
Hospital Clínic i Provincial de Barcelona
RECRUITING

Barcelona, Spain

Contact
Hospital Clínico Universitario Lozano Blesa
RECRUITING

Zaragoza, Spain

Contact
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

Murcia, Spain

Contact
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Spain

Contact
Hospital General Universitario Dr. Balmis (Alicante)
RECRUITING

Alicante, Spain

Contact
Hospital Provincial de Castellón
RECRUITING

Castellon, Spain

Contact
Hospital Quirónsalud Sagrado Corazón
RECRUITING

Seville, Spain

Contact
Hospital San Pedro de Alcántara
RECRUITING

Cáceres, Spain

Contact
Hospital Universitari Dexeus
RECRUITING

Barcelona, Barcelona, Spain

Contact
Hospital Universitari Sant Joan de Reus
RECRUITING

Tarragona, Spain

Contact
Hospital Universitari Son Espases
RECRUITING

Palma de Mallorca, Spain

Contact
Hospital Universitari Vall D'Hebron
RECRUITING

Barcelona, Spain

Contact
Hospital Universitario Arnau de Vilanova de Lleida
RECRUITING

Lleida, Spain

Contact
Hospital Universitario Clínico San Cecilio de Granada
RECRUITING

Granada, Spain

Contact
Hospital Universitario Doce de Octubre
RECRUITING

Madrid, Spain

Contact
Hospital Universitario Insular de Gran Canaria
RECRUITING

Las Palmas de Gran Canaria, Spain

Contact
Hospital Universitario La Paz
RECRUITING

Madrid, Spain

Contact
Hospital Universitario La Ribera - Alzira
RECRUITING

Valencia, Spain

Contact
Hospital Universitario Marqués de Valdecilla
RECRUITING

Valdecilla, Spain

Contact
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Madrid, Spain

Contact
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Spain

Contact
Hospital Universitario San Juan de Alicante
RECRUITING

Alicante, Spain

Contact
Hospital Universitario Sanchinarro-START-CIOCC
RECRUITING

Madrid, Spain

Contact
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Spain

Contact
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Spain

Contact
Hospital Universitario de Basurto
RECRUITING

Bilbao, Spain

Contact
Hospital Universitario de Burgos
RECRUITING

Burgos, Spain

Contact
Hospital Universitario de Canarias
RECRUITING

Santa Cruz de Tenerife, Spain

Contact
Hospital Universitario de León
RECRUITING

León, Spain

Contact
Hospital del Mar
RECRUITING

Barcelona, Spain

Contact
Hospital prive des Cotes d'Amor
RECRUITING

Plérin, France

Contact
Hospitalario Universitario de Navarra
RECRUITING

Pamplona, Spain

Contact
Hämatologie-Onkologie im Zentrum MVZ GmbH
NOT_YET_RECRUITING

Augsburg, Germany

Contact
IRCCS Ospedale Policlinico San Martino
NOT_YET_RECRUITING

Genova, Italy

Contact
IRCCS San Gerardo
NOT_YET_RECRUITING

Monza, Italy

Contact
IUCT Oncopole
RECRUITING

Toulouse, France

Contact
Institut Bergonié Bordeaux
NOT_YET_RECRUITING

Bordeaux, France

Contact
Institut Català d' Oncologia Badalona (ICO)
RECRUITING

Badalona, Spain

Contact
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, France

Contact
Institute de Cancerologie de Lorraine - Nancy
RECRUITING

Vandœuvre-lès-Nancy, France

Contact
Instituto Europeo di Oncologia
RECRUITING

Milan, Italy

Contact
Klinikum Worms - Frauenklinik
RECRUITING

Worms, Germany

Contact
MD Anderson Cancer Center Madrid
RECRUITING

Madrid, Spain

Contact
MVZ II der Niels Stensen Kliniken
RECRUITING

Georgsmarienhütte, Germany

Contact
MVZ Klinikum Aschaffenburg
NOT_YET_RECRUITING

Aschaffenburg, Germany

Contact
Masaryk Memorial Cancer Institute
RECRUITING

Brno, Czechia

Contact
Medical University of Vienna
NOT_YET_RECRUITING

Vienna, Austria

Contact
Medizinische Universität Innsbruck
RECRUITING

Innsbruck, Austria

Contact
Metropolitan General Hospital 4th department
RECRUITING

Athens, Greece

Contact
Metropolitan Hospital Greece 1st department
RECRUITING

Piraeus, Greece

Contact
Multiscan Nemocnice Horovice
RECRUITING

Hořovice, Czechia

Contact
NOB Ondina
NOT_YET_RECRUITING

Salvador, Brazil

Contact
Oncologia Medica AUSL Piacenza
RECRUITING

Piacenza, Italy

Contact
Ordensklinikum Linz Barmherzige Schwestern
RECRUITING

Linz, Austria

Contact
Ordination Priv.-Doz. Dr. Michael Hubalek
RECRUITING

Schwaz, Austria

Contact
Ospedali Riuniti Livorno
RECRUITING

Livorno, Italy

Contact
Policlinico A. Gemelli IRCCS
NOT_YET_RECRUITING

Roma, Italy

Contact
Polyclinique Bordeaux Nord Aquitaine
RECRUITING

Bordeau, France

Contact
Royal Cornwall Hospital NHS Trust
RECRUITING

Truro, United Kingdom

Contact
Royal Surrey County Hospital
RECRUITING

Surrey Quays, United Kingdom

Contact
Städtisches Klinikum Dessau
NOT_YET_RECRUITING

Dessau, Germany

Contact
Tacchini Instituto de Pesquisa
NOT_YET_RECRUITING

Bento Gonçalves, Brazil

Contact
Tomas Bata Regional Hospital in Zlin
RECRUITING

Zlín, Czechia

Contact
UPCO - Hospital de Clinicas de Porto Alegre
NOT_YET_RECRUITING

Porto Alegre, Brazil

Contact
University General Hospital Alexandroupoli
RECRUITING

Alexandroupoli, Greece

Contact
University General Hospital of Heraklion
RECRUITING

Heraklion, Greece

Contact
University General Hospital of Larissa
RECRUITING

Larissa, Greece

Contact
University Hospital Olomouc
NOT_YET_RECRUITING

Olomouc, Czechia

Contact
Universitätsklinikum Dusseldorf
NOT_YET_RECRUITING

Düsseldorf, Germany

Contact
Universitätsklinikum Essen
NOT_YET_RECRUITING

Essen, Germany

Contact
Western General Hospital
NOT_YET_RECRUITING

Edinburgh, United Kingdom

Contact

Conditions

Explore the condition pages connected to this study.

ADVANCED BREAST CANCER ER POSITIVE BREAST CANCER ER-POSITIVE BREAST CANCER ESR1 GENE MUTATION HER2-NEGATIVE BREAST CANCER