Medsir

This study tests whether giving the drug niraparib again after surgery can help women with ovarian cancer whose disease has come back in just a few spots. About 30 participants will take niraparib pills for as long as they work. The goal is to see if this approach can delay the c…

This study tests a drug called repotrectinib in 20 people with a specific type of lung cancer (ROS1-positive) that has spread to the brain. The goal is to see if the drug can shrink or control brain tumors. Participants take the drug by mouth, and doctors monitor safety and how w…

This study tests whether adding everolimus to elacestrant works better than elacestrant alone for people with a certain type of advanced breast cancer (ER+/HER2- with an ESR1 mutation). About 240 adults whose cancer has worsened after standard hormone therapy and CDK4/6 inhibitor…

This study tests a drug called trastuzumab deruxtecan (T-DXd) against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with advanced breast cancer that is hormone receptor-positive and HER2-low or ultralow. The trial includes 200 adults whose cancer has a …

This study looks at whether a simple blood test can find signs of breast cancer returning before it shows up on scans. About 976 people who had surgery for a common type of early breast cancer will give blood samples over time. If the test detects cancer DNA, participants may rec…