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Blood test may spot breast cancer return before symptoms appear

NCT ID NCT05708235

Recruiting now Disease control Sponsor: MedSIR Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a blood test that looks for cancer DNA (ctDNA) can find breast cancer returning earlier than usual scans or exams. About 976 people with HR-positive/HER2-negative early breast cancer who had surgery will give blood samples over time. If the test shows signs of cancer, 40 participants will receive one of three drug combinations (giredestrant alone, with abemaciclib, or with inavolisib) to see if the treatment can clear the cancer DNA from the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
giredestrant, abemaciclib, inavolisib
What this could lead to
If successful, this approach could allow doctors to detect breast cancer recurrence earlier and treat it more effectively, potentially preventing full relapse.
What could go wrong
This is an early phase 2 study with small groups, so results may not apply broadly. The drugs can cause side effects like fatigue, low blood cell counts, and liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Barts Cancer Institute

    RECRUITING

    London, United Kingdom

  • Clínica Universidad de Navarra

    RECRUITING

    Madrid, Spain

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    RECRUITING

    A Coruña, Spain

  • Complejo Hospitalario Universitario de Vigo

    RECRUITING

    Vigo, Spain

  • Complejo Hospitalario de Jaén

    RECRUITING

    Jaén, Spain

  • Fundació Althaia

    RECRUITING

    Barcelona, Spain

  • Hospital Arnau de Vilanova de Valencia

    RECRUITING

    Valencia, Spain

  • Hospital Beata María Ana

    RECRUITING

    Madrid, Spain

  • Hospital Clínic i Provincial de Barcelona

    RECRUITING

    Barcelona, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    RECRUITING

    Murcia, Spain

  • Hospital Clínico Universitario de Valencia

    RECRUITING

    Valencia, Spain

  • Hospital General Universitario Dr. Balmis

    RECRUITING

    Alicante, Spain

  • Hospital Marina Salud de Denia

    RECRUITING

    Alicante, Spain

  • Hospital Provincial de Castellón

    RECRUITING

    Castellon, Spain

  • Hospital Quirónsalud Sagrado Corazón

    RECRUITING

    Seville, Spain

  • Hospital Regional Universitario de Málaga (Hospital Carlos Haya)

    RECRUITING

    Málaga, Spain

  • Hospital Universitari Dexeus

    RECRUITING

    Barcelona, Spain

  • Hospital Universitari Sant Joan de Reus

    RECRUITING

    Tarragona, Spain

  • Hospital Universitari i Politècnic La Fe

    RECRUITING

    Valencia, Spain

  • Hospital Universitario Arnau de Vilanova de Lleida

    RECRUITING

    Lleida, Spain

  • Hospital Universitario Clínico San Cecilio de Granada

    RECRUITING

    Granada, Spain

  • Hospital Universitario Doce de Octubre

    RECRUITING

    Madrid, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Spain

  • Hospital Universitario La Ribera, Alzira

    RECRUITING

    Valencia, Spain

  • Hospital Universitario Miguel Servet

    RECRUITING

    Zaragoza, Spain

  • Hospital Universitario Reina Sofía

    RECRUITING

    Córdoba, Spain

  • Hospital Universitario Sanchinarro-START-CIOCC

    RECRUITING

    Madrid, Spain

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, Spain

  • Hospital Universitario Virgen del Rocío

    RECRUITING

    Seville, Spain

  • Hospital Universitario de Basurto

    RECRUITING

    Bilbao, Spain

  • Hospital Universitario de León

    RECRUITING

    León, Spain

  • Hospital Universitario de Torrejón

    RECRUITING

    Madrid, Spain

  • Hospital Virgen de los Lirios

    RECRUITING

    Alicante, Spain

  • Hospital de Sagunto

    RECRUITING

    Sagunto, Spain

  • Hospital de Xativa

    RECRUITING

    Xàtiva, Spain

  • Hospital del Vinalopó

    RECRUITING

    Elche, Spain

  • Hospitalario Universitario de Navarra

    RECRUITING

    Pamplona, Spain

  • Imperial College Healthcare NHS Trust

    RECRUITING

    London, United Kingdom

  • Institut Català d' Oncologia Girona (ICO)

    RECRUITING

    Girona, Spain

  • Royal Surrey County Hospital NHS Foundation Trust

    RECRUITING

    Guildford, United Kingdom

  • University Hospital Coventry

    RECRUITING

    Coventry, United Kingdom

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