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New drug shows promise for Hard-to-Treat breast cancer subtype

NCT ID NCT06486883

Recruiting now Disease control Sponsor: MedSIR Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called trastuzumab deruxtecan (T-DXd) against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with a certain type of advanced breast cancer. The cancer must be hormone receptor-positive, HER2-low or ultralow, and have a specific gene pattern called non-luminal. About 200 participants will be randomly assigned to one of the two treatments to see which works better at delaying cancer growth.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER ADVANCED BREAST CARCINOMA HORMONE RECEPTOR-POSITIVE BREAST CARCINOMA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O.U. Ospedali Riuniti di Ancona

    RECRUITING

    Ancona, 60126, Italy

  • AOU Careggi

    RECRUITING

    Florence, 50134, Italy

  • Algemeen Ziekenhuis Klina

    RECRUITING

    Brasschaat, Belgium

  • Azienda Ospedaliero- Universitaria Maggiore Della Carita

    RECRUITING

    Novara, 28100, Italy

  • Barts Health NHS Trust

    RECRUITING

    London, United Kingdom

  • CHU Helora - Hopital de Mons

    RECRUITING

    Mons, Belgium

  • CHU Lyon Sud

    RECRUITING

    Lyon, France

  • CHU Saint Etienne

    RECRUITING

    Saint-Priest-en-Jarez, 42055, France

  • Centre Francois Baclesse

    RECRUITING

    Caen, France

  • Centro Oncológico de Galicia

    RECRUITING

    A Coruña, 15009, Spain

  • Centro di Riferimento Oncologico di Aviano

    RECRUITING

    Aviano, 33081, Italy

  • Cliniques universitaires Saint-Luc

    RECRUITING

    Woluwe-Saint-Lambert, Belgium

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    RECRUITING

    A Coruña, 15006, Spain

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    RECRUITING

    Santiago de Compostela, 15706, Spain

  • Complejo Hospitalario de Jaén

    RECRUITING

    Jaén, Jaén, 23007, Spain

  • Federico II Napoli

    RECRUITING

    Naples, 80131, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli

    RECRUITING

    Roma, 00168, Italy

  • Ghent University Hospital

    RECRUITING

    Ghent, Belgium

  • Hospital Arnau de Vilanova de Valencia

    RECRUITING

    Valencia, Spain

  • Hospital Beata María Ana

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Beatriz Ângelo

    RECRUITING

    Loures, Portugal

  • Hospital Clínic i Provincial de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clínico San Carlos

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Clínico Universitario Lozano Blesa

    RECRUITING

    Zaragoza, 50009, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    RECRUITING

    Murcia, Murcia, 30120, Spain

  • Hospital Clínico Universitario de Valencia

    RECRUITING

    Valencia, Valencia, 46010, Spain

  • Hospital Da Luz Lisboa

    RECRUITING

    Lisbon, Portugal

  • Hospital QuirónSalud Zaragoza

    RECRUITING

    Zaragoza, 50012, Spain

  • Hospital Quirónsalud Sagrado Corazón

    RECRUITING

    Barcelona, Barcelona, 41013, Spain

  • Hospital San Pedro de Alcántara

    RECRUITING

    Cáceres, Cáceres, 1003, Spain

  • Hospital Universitari Dexeus

    RECRUITING

    Barcelona, 08028, Spain

  • Hospital Universitari Sant Joan de Reus

    RECRUITING

    Reus, Tarragona, 43204, Spain

  • Hospital Universitari i Politècnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario Arnau de Vilanova de Lleida

    RECRUITING

    Lleida, 25198, Spain

  • Hospital Universitario Clínico San Cecilio

    RECRUITING

    Granada, Granada, 18007, Spain

  • Hospital Universitario Doce de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    RECRUITING

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Madrid, 28034, Spain

  • Hospital Universitario San Juan de Alicante

    RECRUITING

    Alicante, 03550, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, 41009, Spain

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, 29010, Spain

  • Hospital Universitario de Basurto

    RECRUITING

    Bilbao, 48013, Spain

  • Hospital de Cascais

    RECRUITING

    Alcabideche, 2755-009, Portugal

  • Institut Català d' Oncologia Badalona (ICO)

    RECRUITING

    Badalona, 08916, Spain

  • Institut Català d' Oncologia Girona (ICO)

    RECRUITING

    Girona, Girona, 17007, Spain

  • Institut Curie

    RECRUITING

    Paris, France

  • Institute Paoli Calmettes

    RECRUITING

    Marseille, France

  • Instituto Europeo di Oncologia

    RECRUITING

    Milan, 20141, Italy

  • Instituto Portugues Oncologia de Porto (IPO)

    RECRUITING

    Porto, Portugal

  • Instituto Valenciano de Oncología (IVO)

    RECRUITING

    Valencia, 46009, Spain

  • Istituto Nazionale Tumori Irccs "Fondazione G Pascale"

    RECRUITING

    Naples, 80131, Italy

  • Istituto Oncologico Veneto

    RECRUITING

    Padova, Italy

  • Kepler Universitäts Klinikum

    RECRUITING

    Linz, Austria

  • Kliniken Essen Mitte

    RECRUITING

    Essen, Germany

  • Klinikum Worms - Frauenklinik

    RECRUITING

    Worms, 67550, Germany

  • MVZ Klinikum Aschaffenburg

    RECRUITING

    Aschaffenburg, Germany

  • Medical University of Vienna

    RECRUITING

    Vienna, Austria

  • Medtrials Sp. z o.o.

    RECRUITING

    Krakow, Poland

  • Oncologia medica AUSL Piacenza

    RECRUITING

    Piacenza, 29100, Italy

  • Ospedale Policlinico San Martino

    RECRUITING

    Genova, 16132, Italy

  • Ospedale Sacro Cuore Don Calabria Negrar

    RECRUITING

    Negrar, Italy

  • Ospedale San Gerardo

    RECRUITING

    Monza, 20900, Italy

  • Ospedale di Macerata

    RECRUITING

    Province of Macerata, 62100, Italy

  • Royal United Hospitals Bath NHS Foundation Trust

    RECRUITING

    Bath, United Kingdom

  • The Christie NHS Foundation Trust

    RECRUITING

    Lancaster, United Kingdom

  • UOMI Cancer Center

    RECRUITING

    Barcelona, 08017, Spain

  • Unidade Local de Saúde Amadora/Sintra - Hospital Fernando da Fonseca

    RECRUITING

    Amadora, 2720-276, Portugal

  • Unidade Local de Saúde da Região de Aveiro

    RECRUITING

    Aveiro, Portugal

  • Unidade Local de Saúde de Santa Maria

    RECRUITING

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saúde de Santo António

    RECRUITING

    Porto, Portugal

  • Unidade Local de Saúde de Trás-os-Montes e Alto Douro

    RECRUITING

    Lordelo, Vila Real District, 5000-508, Portugal

  • Unidade Local de Saúde do Alto Ave

    RECRUITING

    Braga, Portugal