New drug shows promise for Hard-to-Treat breast cancer in phase 2 trial

NCT ID NCT06486883

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 26 times

Summary

This study tests a drug called trastuzumab deruxtecan (T-DXd) against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with advanced breast cancer that is hormone receptor-positive and HER2-low or ultralow. The trial includes 200 adults whose cancer has a specific gene pattern. The goal is to see if T-DXd works better at delaying cancer growth.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O.U. Ospedali Riuniti di Ancona

    RECRUITING

    Ancona, 60126, Italy

  • AOU Careggi

    RECRUITING

    Florence, 50134, Italy

  • Algemeen Ziekenhuis Klina

    RECRUITING

    Brasschaat, Belgium

  • Azienda Ospedaliero- Universitaria Maggiore Della Carita

    RECRUITING

    Novara, 28100, Italy

  • CHU Helora - Hopital de Mons

    RECRUITING

    Mons, Belgium

  • CHU Lyon Sud

    RECRUITING

    Lyon, France

  • CHU Saint Etienne

    RECRUITING

    Saint-Priest-en-Jarez, 42055, France

  • Centro Oncológico de Galicia

    RECRUITING

    A Coruña, 15009, Spain

  • Centro di Riferimento Oncologico di Aviano

    RECRUITING

    Aviano, 33081, Italy

  • Cliniques universitaires Saint-Luc

    RECRUITING

    Woluwe-Saint-Lambert, Belgium

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    RECRUITING

    A Coruña, 15006, Spain

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    RECRUITING

    Santiago de Compostela, 15706, Spain

  • Complejo Hospitalario de Jaén

    RECRUITING

    Jaén, Jaén, 23007, Spain

  • Federico II Napoli

    RECRUITING

    Naples, 80131, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli

    RECRUITING

    Roma, 00168, Italy

  • Hospital Arnau de Vilanova de Valencia

    RECRUITING

    Valencia, Spain

  • Hospital Beata María Ana

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Clínic i Provincial de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clínico San Carlos

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Clínico Universitario Lozano Blesa

    RECRUITING

    Zaragoza, 50009, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    RECRUITING

    Murcia, Murcia, 30120, Spain

  • Hospital Clínico Universitario de Valencia

    RECRUITING

    Valencia, Valencia, 46010, Spain

  • Hospital QuirónSalud Zaragoza

    RECRUITING

    Zaragoza, 50012, Spain

  • Hospital Quirónsalud Sagrado Corazón

    RECRUITING

    Barcelona, Barcelona, 41013, Spain

  • Hospital San Pedro de Alcántara

    RECRUITING

    Cáceres, Cáceres, 1003, Spain

  • Hospital Universitari Dexeus

    RECRUITING

    Barcelona, 08028, Spain

  • Hospital Universitari Sant Joan de Reus

    RECRUITING

    Reus, Tarragona, 43204, Spain

  • Hospital Universitari i Politècnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario Arnau de Vilanova de Lleida

    RECRUITING

    Lleida, 25198, Spain

  • Hospital Universitario Clínico San Cecilio

    RECRUITING

    Granada, Granada, 18007, Spain

  • Hospital Universitario Doce de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Puerta de Hierro Majadahonda

    RECRUITING

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Madrid, 28034, Spain

  • Hospital Universitario San Juan de Alicante

    RECRUITING

    Alicante, 03550, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, 41009, Spain

  • Hospital Universitario Virgen de la Victoria

    RECRUITING

    Málaga, 29010, Spain

  • Hospital Universitario de Basurto

    RECRUITING

    Bilbao, 48013, Spain

  • Hospital de Cascais

    RECRUITING

    Alcabideche, 2755-009, Portugal

  • Institut Català d' Oncologia Badalona (ICO)

    RECRUITING

    Badalona, 08916, Spain

  • Institut Català d' Oncologia Girona (ICO)

    RECRUITING

    Girona, Girona, 17007, Spain

  • Institut Curie

    RECRUITING

    Paris, France

  • Instituto Europeo di Oncologia

    RECRUITING

    Milan, 20141, Italy

  • Instituto Portugues Oncologia de Porto (IPO)

    RECRUITING

    Porto, Portugal

  • Instituto Valenciano de Oncología (IVO)

    RECRUITING

    Valencia, 46009, Spain

  • Istituto Nazionale Tumori Irccs "Fondazione G Pascale"

    RECRUITING

    Naples, 80131, Italy

  • Klinikum Worms - Frauenklinik

    RECRUITING

    Worms, 67550, Germany

  • Medtrials Sp. z o.o.

    RECRUITING

    Krakow, Poland

  • Oncologia medica AUSL Piacenza

    RECRUITING

    Piacenza, 29100, Italy

  • Ospedale Policlinico San Martino

    RECRUITING

    Genova, 16132, Italy

  • Ospedale San Gerardo

    RECRUITING

    Monza, 20900, Italy

  • Ospedale di Macerata

    RECRUITING

    Macerata, 62100, Italy

  • UOMI Cancer Center

    RECRUITING

    Barcelona, 08017, Spain

  • Unidade Local de Saúde Amadora/Sintra - Hospital Fernando da Fonseca

    RECRUITING

    Amadora, 2720-276, Portugal

  • Unidade Local de Saúde de Santa Maria

    RECRUITING

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saúde de Trás-os-Montes e Alto Douro

    RECRUITING

    Lordelo, Vila Real District, 5000-508, Portugal

  • Unidade Local de Saúde do Alto Ave

    RECRUITING

    Braga, Portugal

Conditions

Explore the condition pages connected to this study.