New drug shows promise for Hard-to-Treat breast cancer subtype

NCT ID NCT06486883

Recruiting now Disease control Sponsor: MedSIR Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tests a drug called trastuzumab deruxtecan (T-DXd) against the usual treatment (a CDK4/6 inhibitor plus hormone therapy) for people with a certain type of advanced breast cancer. The cancer must be hormone receptor-positive, HER2-low or ultralow, and have a specific gene pattern called non-luminal. About 200 participants will be randomly assigned to one of the two treatments to see which works better at delaying cancer growth.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED BREAST CANCER ADVANCED BREAST CARCINOMA HORMONE RECEPTOR POSITIVE BREAST CARCINOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

A.O.U. Ospedali Riuniti di Ancona
RECRUITING

Ancona, 60126, Italy
AOU Careggi
RECRUITING

Florence, 50134, Italy
AOU policlinico di Modena
RECRUITING

Modena, Italy
Algemeen Ziekenhuis Klina
RECRUITING

Brasschaat, Belgium
Azienda Ospedaliero- Universitaria Maggiore Della Carita
RECRUITING

Novara, 28100, Italy
Barts Health NHS Trust
RECRUITING

London, United Kingdom
CHU Helora - Hopital de Mons
RECRUITING

Mons, Belgium
CHU Lyon Sud
RECRUITING

Lyon, France
CHU Saint Etienne
RECRUITING

Saint-Priest-en-Jarez, 42055, France
Centre Francois Baclesse
RECRUITING

Caen, France
Centro Oncológico de Galicia
RECRUITING

A Coruña, 15009, Spain
Centro di Riferimento Oncologico di Aviano
RECRUITING

Aviano, 33081, Italy
Cliniques universitaires Saint-Luc
RECRUITING

Woluwe-Saint-Lambert, Belgium
Complejo Hospitalario Universitario A Coruña (CHUAC)
RECRUITING

A Coruña, 15006, Spain
Complejo Hospitalario Universitario de Santiago (CHUS)
RECRUITING

Santiago de Compostela, 15706, Spain
Complejo Hospitalario de Jaén
RECRUITING

Jaén, Jaén, 23007, Spain
Federico II Napoli
RECRUITING

Naples, 80131, Italy
Fondazione Policlinico Universitario Agostino Gemelli
RECRUITING

Roma, 00168, Italy
Ghent University Hospital
RECRUITING

Ghent, Belgium
Hospital Arnau de Vilanova de Valencia
RECRUITING

Valencia, Spain
Hospital Beata María Ana
RECRUITING

Madrid, 28007, Spain
Hospital Beatriz Ângelo
RECRUITING

Loures, Portugal
Hospital Clínic i Provincial de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Clínico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clínico Universitario Lozano Blesa
RECRUITING

Zaragoza, 50009, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

Murcia, Murcia, 30120, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain
Hospital Da Luz Lisboa
RECRUITING

Lisbon, Portugal
Hospital Gregorio Marañón
RECRUITING

Madrid, Spain
Hospital QuirónSalud Zaragoza
RECRUITING

Zaragoza, 50012, Spain
Hospital Quirónsalud Sagrado Corazón
RECRUITING

Barcelona, Barcelona, 41013, Spain
Hospital San Pedro de Alcántara
RECRUITING

Cáceres, Cáceres, 1003, Spain
Hospital Universitari Dexeus
RECRUITING

Barcelona, 08028, Spain
Hospital Universitari Sant Joan de Reus
RECRUITING

Reus, Tarragona, 43204, Spain
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Arnau de Vilanova de Lleida
RECRUITING

Lleida, 25198, Spain
Hospital Universitario Clínico San Cecilio
RECRUITING

Granada, Granada, 18007, Spain
Hospital Universitario Doce de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Madrid, 28034, Spain
Hospital Universitario San Juan de Alicante
RECRUITING

Alicante, 03550, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital Universitario de Basurto
RECRUITING

Bilbao, 48013, Spain
Hospital de Cascais
RECRUITING

Alcabideche, 2755-009, Portugal
Hämatologie-Onkologie im Zentrum MVZ
RECRUITING

Augsburg, Germany
Institut Català d' Oncologia Badalona (ICO)
RECRUITING

Badalona, 08916, Spain
Institut Català d' Oncologia Girona (ICO)
RECRUITING

Girona, Girona, 17007, Spain
Institut Curie
RECRUITING

Paris, France
Institute Paoli Calmettes
RECRUITING

Marseille, France
Instituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Instituto Portugues Oncologia de Porto (IPO)
RECRUITING

Porto, Portugal
Instituto Valenciano de Oncología (IVO)
RECRUITING

Valencia, 46009, Spain
Istituto Nazionale Tumori Irccs "Fondazione G Pascale"
RECRUITING

Naples, 80131, Italy
Istituto Oncologico Veneto
RECRUITING

Padova, Italy
Kepler Universitäts Klinikum
RECRUITING

Linz, Austria
Kliniken Essen Mitte
RECRUITING

Essen, Germany
Klinikum Worms - Frauenklinik
RECRUITING

Worms, 67550, Germany
MVZ Klinikum Aschaffenburg
RECRUITING

Aschaffenburg, Germany
Medical University of Vienna
RECRUITING

Vienna, Austria
Medizinische Universität Graz
RECRUITING

Graz, Austria
Medtrials Sp. z o.o.
RECRUITING

Krakow, Poland
Netherlands Cancer Institute
RECRUITING

Amsterdam, Netherlands
Oncologia medica AUSL Piacenza
RECRUITING

Piacenza, 29100, Italy
Ospedale Policlinico San Martino
RECRUITING

Genova, 16132, Italy
Ospedale Sacro Cuore Don Calabria Negrar
RECRUITING

Negrar, Italy
Ospedale San Gerardo
RECRUITING

Monza, 20900, Italy
Ospedale di Macerata
RECRUITING

Province of Macerata, 62100, Italy
Royal United Hospitals Bath NHS Foundation Trust
RECRUITING

Bath, United Kingdom
The Christie NHS Foundation Trust
RECRUITING

Lancaster, United Kingdom
UOMI Cancer Center
RECRUITING

Barcelona, 08017, Spain
Unidade Local de Saúde Amadora/Sintra - Hospital Fernando da Fonseca
RECRUITING

Amadora, 2720-276, Portugal
Unidade Local de Saúde da Região de Aveiro
RECRUITING

Aveiro, Portugal
Unidade Local de Saúde de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
Unidade Local de Saúde de Santo António
RECRUITING

Porto, Portugal
Unidade Local de Saúde de Trás-os-Montes e Alto Douro
RECRUITING

Lordelo, Vila Real District, 5000-508, Portugal
Unidade Local de Saúde do Alto Ave
RECRUITING

Braga, Portugal
Universitätsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, Germany
Wojskowy Instytut Medyczny
RECRUITING

Legionowo, Poland

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