Medsir

This early-stage trial tests a new type of drug that can both find and treat cancer that has spread to the brain. The study includes 10 adults with solid tumors, specifically HER2-positive breast cancer, that have active brain metastases. The goal is to see if the drug can target…

This study tests a combination of two drugs, camizestrant and ribociclib, in 150 adults with advanced hormone receptor-positive (HR+) breast cancer. Participants must have had at least 5 years of prior hormone therapy. The goal is to see if the combination can delay cancer growth…

This study tests a new drug called bexmarilimab (an antibody) combined with the chemotherapy doxorubicin in people with metastatic soft-tissue sarcoma (a type of cancer that has spread). The goal is to find the safest dose and see if the combination helps control tumor growth. Ab…

This study tests a new combination of two targeted drugs (zanidatamab and tucatinib) plus chemotherapy in people with HER2-positive advanced breast cancer that cannot be removed by surgery or has spread. The goal is to find the safest dose and see if the combo helps shrink tumors…

This study tests whether giving atropine before chemotherapy can prevent severe diarrhea in people with advanced breast cancer. About 30 participants will receive atropine alongside the drug sacituzumab govitecan. The goal is to make treatment more tolerable by reducing a common …

This study will examine stored tumor samples from 244 people diagnosed with biliary tract cancer in the last 15 years. Researchers will measure five specific markers (CLDN18.2, HER2, TROP2, PD-L1, and B7-H4) to see how they relate to patient outcomes. The goal is to better group …