ESR1 GENE MUTATION
Clinical trials for ESR1 GENE MUTATION explained in plain language.
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New combo aims to outsmart resistant breast cancer
Disease control Recruiting nowThis study compares two treatments for advanced estrogen receptor-positive (ER+) breast cancer that has stopped responding to standard therapies. About 297 participants will receive either a combination of elacestrant and capecitabine or capecitabine alone. The goal is to see if …
Matched conditions: ESR1 GENE MUTATION
Phase: PHASE2 • Sponsor: Kristina A. Fanucci • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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Promising combo targets Hard-to-Treat breast cancer
Disease control Recruiting nowThis study tests whether adding everolimus to elacestrant works better than elacestrant alone for people with a certain type of advanced breast cancer (ER+/HER2- with an ESR1 mutation). About 240 adults whose cancer has worsened after standard hormone therapy and CDK4/6 inhibitor…
Matched conditions: ESR1 GENE MUTATION
Phase: PHASE3 • Sponsor: MedSIR • Aim: Disease control
Last updated May 12, 2026 13:41 UTC
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Smart scans aim to personalize tamoxifen dosing for Drug-Resistant breast cancer
Disease control Recruiting nowThis study tests whether a special PET scan (FES-PET) can help find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participants and use the s…
Matched conditions: ESR1 GENE MUTATION
Phase: EARLY_PHASE1 • Sponsor: University of Wisconsin, Madison • Aim: Disease control
Last updated May 06, 2026 16:14 UTC