ESR1 GENE MUTATION
Clinical trials for ESR1 GENE MUTATION explained in plain language.
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Promising drug combo aims to control advanced breast cancer when standard therapy fails
Disease control Recruiting nowThis study compares a combination of two drugs (elacestrant and capecitabine) to capecitabine alone in people with advanced estrogen receptor-positive breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to one of the two t…
Matched conditions: ESR1 GENE MUTATION
Phase: PHASE2 • Sponsor: Kristina A. Fanucci • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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Promising combo aims to stall advanced breast cancer
Disease control Recruiting nowThis study tests whether adding everolimus to elacestrant can help people with a certain type of advanced breast cancer (ER+/HER2- with an ESR1 mutation) live longer without their cancer getting worse. About 240 adults whose cancer has stopped responding to standard hormone thera…
Matched conditions: ESR1 GENE MUTATION
Phase: PHASE3 • Sponsor: MedSIR • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Personalized tamoxifen dosing: can a PET scan show the way?
Knowledge-focused Recruiting nowThis pilot study tests whether a special PET scan (FES-PET/CT) can help doctors find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participa…
Matched conditions: ESR1 GENE MUTATION
Phase: EARLY_PHASE1 • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC