Could HIV drugs help fight brain cancer? new trial launches

NCT ID NCT06428045

Recruiting now Disease control Sponsor: University of Miami Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a combination of antiretroviral drugs (normally used for HIV) and a laser procedure to treat high-grade gliomas—aggressive brain tumors that cannot be surgically removed. About 24 adults with newly diagnosed tumors will receive the laser treatment followed by daily antiretroviral pills. The main goals are to check safety and see if the tumors respond.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Abacavir, Lamivudine, and Ritonavir (antiretroviral drugs) combined with MR-guided laser interstitial thermal therapy (LITT)
What this could lead to: If this works, it could point toward a new treatment option for high-grade gliomas that cannot be surgically removed, potentially slowing tumor growth.
What could go wrong: This is a very early Phase 1 trial with only 24 participants, focused mainly on safety. The combination may cause serious side effects, and it is too soon to know if it will effectively control the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH GRADE GLIOMA

Contacts and locations

Locations

University of Miami
RECRUITING

Miami, Florida, 33136, United States

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