Could HIV drugs help fight brain cancer? new trial launches
NCT ID NCT06428045
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tests a combination of antiretroviral drugs (normally used for HIV) and a laser procedure to treat high-grade gliomas—aggressive brain tumors that cannot be surgically removed. About 24 adults with newly diagnosed tumors will receive the laser treatment followed by daily antiretroviral pills. The main goals are to check safety and see if the tumors respond.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Abacavir, Lamivudine, and Ritonavir (antiretroviral drugs) combined with MR-guided laser interstitial thermal therapy (LITT)
What this could lead to
If this works, it could point toward a new treatment option for high-grade gliomas that cannot be surgically removed, potentially slowing tumor growth.
What could go wrong
This is a very early Phase 1 trial with only 24 participants, focused mainly on safety. The combination may cause serious side effects, and it is too soon to know if it will effectively control the disease.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HIGH GRADE GLIOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact