Low-Nicotine smokes put to the heart test
NCT ID NCT05707871
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase study is testing whether cigarettes with very low nicotine content cause less strain on the heart compared to regular cigarettes. Researchers will measure heart rate and heart rate variability in 49 daily and non-daily smokers after smoking different types of research cigarettes. The goal is to gather basic evidence on cardiovascular effects, which could guide future tobacco policies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- very low nicotine content cigarettes
- What this could lead to
- If successful, this could help understand whether reducing nicotine in cigarettes lowers cardiovascular harm, potentially informing future tobacco regulation.
- What could go wrong
- This is a very early, small study (49 participants) measuring short-term heart rate changes, not long-term health outcomes. Results may not apply to real-world smoking patterns.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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