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E-Cigarettes vs. medication: a new hope for stubborn smokers?

NCT ID NCT06373679

Disease control Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study compares e-cigarettes to FDA-approved medications (nicotine replacement therapy or varenicline) for helping smokers who have previously failed to quit. Participants are randomly assigned to one of two groups and can choose their preferred product within that group. The goal is to see if switching to e-cigarettes leads to more successful quitting than traditional methods.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
e-cigarette, varenicline, nicotine replacement therapy
What this could lead to
If successful, this could offer a harm reduction option for smokers who have not been able to quit with standard treatments.
What could go wrong
The trial is relatively small and early-stage, and e-cigarettes carry their own health risks. Success depends on complete switching and long-term abstinence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 225 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Adults 21+ who previously had a quit attempt using FDA-approved pharmacotherapy. * Interest in reducing harms from tobacco use or quitting smoking Exclusion Criteria * Pregnant, breastfeeding, or trying to become pregnant. * Household member currently enrolled in the study * Planning to move out of the area within the next 7 months

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cigarette smoking Smoking behaviors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical Univeristy of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

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