Can E-Cigs help smokers fighting opioid addiction kick the habit?

NCT ID NCT05722561

Recruiting now Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares e-cigarettes to standard counseling and nicotine patches/lozenges for reducing smoking in people with opioid use disorder. About 300 participants who smoke at least 5 cigarettes daily and are in treatment for opioid addiction will be followed for 6 months. The goal is to see if e-cigarettes help them cut down or stop smoking more effectively than current methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: electronic cigarettes and nicotine replacement therapy (lozenges and patches)
What this could lead to: If it works, this could provide a new harm reduction tool to help people with opioid use disorder cut down or quit smoking.
What could go wrong: This is a mid-stage trial with 302 participants, so results may not apply to everyone. E-cigarettes have their own health risks and may not help everyone quit smoking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking opiate dependence Smoking Smoking Reduction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKING OPIOID-USE DISORDER

Contacts and locations

Locations

Albert Einstein College of Medicine
NOT_YET_RECRUITING

The Bronx, New York, 10461, United States
NYU Langone Health
RECRUITING

New York, New York, 10016, United States

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