CIGARETTE SMOKING

This study tests whether changing treatments based on how well a person responds can help smokers quit. Participants will receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks. The study involves 544 adult smokers who want to quit, with all visits don…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch away from smoking cigarettes. Fifty adult smokers will receive a 28-day supply of pouches and be asked to use them instead of cigarettes. Researchers will track how many people quit smokin…

This study looks at whether e-cigarettes or oral nicotine pouches are better at helping people who smoke cigarettes cut down. Two hundred smokers who have tried to quit before will be randomly assigned to use one of these products instead of cigarettes for six weeks. Researchers …

This study compares e-cigarettes to standard nicotine patches and counseling for reducing cigarette smoking in people being treated for opioid use disorder. About 300 adults who smoke at least 5 cigarettes daily will be randomly assigned to one of two groups. The goal is to see i…

This study looks at whether e-cigarettes or nicotine patches and lozenges, combined with counseling and text messages, can help people with serious mental illness reduce their cigarette smoking. 60 participants who smoke at least 5 cigarettes a day will be randomly assigned to on…

This study tests whether a non-invasive brain stimulation technique called TMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to specific brain areas involved in cravings and self-control. The study involves 64 adults who smoke at least 10 c…

This study is for adults who smoke at least 5 cigarettes daily and are not ready to quit in the next month. Participants will be randomly assigned to try either a choice of harm-reduction products (like e-cigarettes or nicotine pouches) or standard nicotine patches and lozenges f…

This study is testing a mobile health app designed to help young adults (ages 18–26) quit or reduce their use of e-cigarettes and other vaping products. About 46 participants will use the app and have their progress tracked through interviews and saliva tests. The goal is to see …

This study tests if a once-weekly injection of semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive the drug or a placebo, and researchers will track changes in body weight, body fat, and appetite…

This study looks at what happens to markers of inflammation in the blood when menthol cigarette smokers switch to non-menthol cigarettes. The goal is to understand if removing menthol could lower heart disease risk. About 68 adult menthol smokers will be followed for several week…

This study looks at how making cigarettes very low in nicotine and changing prices of e-cigarettes and illegal cigarettes might influence what smokers buy. About 70 adult smokers will use a pretend online store to see how they spend their money. The goal is to understand if these…

This study looks at whether the flavor of e-cigarettes helps people who smoke regular cigarettes switch to vaping instead. About 210 smokers will be given fruit, tobacco, or menthol flavored e-cigarettes and asked to use only those for 6 weeks. Researchers will track how many cig…

This study looks at what happens when smokers relight cigarettes that have gone out. Researchers will compare the levels of harmful chemicals in relit versus continuously smoked cigarettes. Thirty smokers who regularly relight will take part, both in their daily life and in a cli…

This study looks at how THC (the active part of cannabis) affects cigarette cravings, smoking habits, and body responses like heart rate and blood pressure. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and cannabis. The goal is to…

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, change brain reactions to smoking cues in daily smokers. About 80 healthy adults who smoke regularly will have MRI scans and report cravings. The goal is to understand the brain mechanis…

This study looks at how different cigarette taxes and nicotine levels change what smokers buy. About 316 daily smokers will shop in a virtual store with various tax plans. The goal is to see if taxes can encourage people to choose less harmful tobacco products.