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Quitting smoking may also ward off diabetes — a trial puts the dual strategy to the test

NCT ID NCT01926041

Prevention Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial investigates whether a smoking cessation program that also helps control weight can reduce the risk of developing type 2 diabetes in people who smoke and have prediabetes. Participants receive varenicline (a quit-smoking medication) along with personalized coaching on diet and physical activity. The study tracks how many go on to develop diabetes versus return to normal blood sugar levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a smoking cessation drug called varenicline plus behavioral coaching on diet and exercise
What this could lead to
If successful, this approach could help prediabetic smokers quit tobacco while avoiding weight gain, potentially preventing or delaying type 2 diabetes.
What could go wrong
This is a single-center study, and results may not apply to all smokers. The program combines drug and behavioral support, so it is unclear which part drives any benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

589 people

The number who actually took part.

Started

Aug 2013

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 30 to 75 years * Prediabetic smokers Exclusion Criteria * existing diagnosis of DM or current use of diabetic medications * thyroid diseases * acute cardiac conditions within 3 months * acute renal failure, chronic glomerulonephritis, or polycystic kidney disease * mental health disorders ever diagnosed by psychiatrists * pregnancy or breast-feeding * malignancy * current use of smoking cessation medications, steroids, lithium, or antipsychotics.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking diabetes mellitus prediabetes syndrome Smoking Cessation type 2 diabetes mellitus prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cigarette smoking Diabetes mellitus Prediabetes

Contacts and locations

Locations

  • National Taiwan University Hospital and its Yunlin branch

    Taipei, Department of Family Medicine, 100, Taiwan

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