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Could a blood pressure drug curb alcohol cravings? new trial investigates

NCT ID NCT03764098

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests whether guanfacine, a drug used for high blood pressure and ADHD, can help people with alcohol use disorder drink less. Researchers will compare guanfacine to a placebo in 160 men and women, measuring alcohol consumption in lab sessions and during a treatment phase. The goal is to see if guanfacine reduces stress- and stimulation-driven drinking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Guanfacine Extended Release (Intuniv)
What this could lead to
If successful, this could point toward a new medication to help people with alcohol use disorder drink less.
What could go wrong
This is an early Phase 2 trial with only 160 people, so results may not apply to everyone. The drug may not reduce drinking more than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse Alcohol Drinking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Yale University School of Medicine

    RECRUITING

    New Haven, Connecticut, 06510, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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